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MicroRNA that involves the negative regulation of reverse cholesterol transport
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1.Affiliated Nanhua Hospital, ;2.Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, China)

Clc Number:

R5

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    Abstract:

    Strengthening the reverse cholesterol transport (RCT) has the anti-atherosclerotic effect. MicroRNA (miRNA) involves the regulation of many biological processes. Recent studies suggest that miRNA can control the ATP binding cassette transporter A1(ABCA1) and scavenger receptor class B type Ⅰ (SR-B Ⅰ) that belong to the critical protein of RCT. Currently, it has been found that many miRNAs can inhibit the levels of SR-B Ⅰ and ABCA1 protein expression, and then inhibiting the cholesterol efflux. This paper summarizes the miRNA that involves the negative regulation of RCT.

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JIANG Bo, LI Dan, LIU Ya-Mi, WANG Zuo, MA Xiao-Feng. MicroRNA that involves the negative regulation of reverse cholesterol transport[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(3):321-324.

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History
  • Received:September 01,2017
  • Revised:December 06,2017
  • Online: April 03,2018
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