2025年6月11日 周三
Home > Archive>Volume 26, Issue 3, 2018 >315-320
PDF HTML XML Export Cite reminder
Diabetes mellitus combined with subclinical hypothyroidism and its impact on atherosclerosis
Author:
Affiliation:

The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716000, China)

Clc Number:

R5

  • Article
    • | |
  • Metrics
    • |
  • Reference [41]
    • | | | |
  • Comments
    Abstract:

    Diabetic macrovascular disease is a complication of diabetes,with the highest incidence,the most harmful and the highest death rate. Subclinical hypothyroidism (SCH) is defined as a plasma thyroid-stimulating hormone (TSH) level above the institutional reference range combined with a plasma free thyroxine (FT4) or free triiodothyronine (FT3) level. In recent years, domestic studies have shown that elevated TSH can be used as an independent risk factor for atherosclerosis (As) through a variety of ways to promote the development of As, and thus participate in the progress of diabetic macroangiopathy. This article reviews the association between SCH and atherosclerosis in diabetic patients by summarizing the relevant literature.

    Reference
    [1] Zhao W, Han C, Shi X, et al.Prevalence of goiter and thyroid nodules before and after implementation of the universal salt iodization program in mainland China from 1985 to 2014:a systematic review and meta-analysis .PLos One, 4,9(10):e109 549.
    [2] Bansal S K, Yadav R.A study of the extended lipid profile including oxidized LDL, small dense LDL, lipoprotein (a) and apolipoproteins in the assessment of cardiovascular risk in hypothyroid patients.J Clinical Diagnostic Res Jcdr, 6,0(6):BC04.
    [3] Zha K, Zuo C, Wang A, et al.LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation.Lipids in Health Dis, 5,4(1):1-8.
    [4] Laloo D, Salam R.Thyroid dysfunction in type 2 diabetes mellitus:A retrospective study.Indian J Endocrinol Metab, 2,6(Suppl 2):S334.
    [5] Furukawa S, Yamamoto S, Todo Y, et al.Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus.Endocr J, 4,1(10):1 011.
    [6] Anagnostis P, Efstathiadou Z, Kita M.Subclinical hypothyroidism and diabetic nephropathy.Could L-thyroxine replacement therapy be of value？.Endocr J, 4,1(10):1 053.
    [7] Raval A D, Sambamoorthi U.Incremental healthcare expenditures associated with thyroid disorders among individuals with diabetes.J Thyroid Res, 2,2(7):418 345.
    [8] Han C, He X, Xia X, et al.Subclinical hypothyroidism and type 2 diabetes:a systematic review and Meta-analysis.Plos One, 5,0(8):e0135 233.
    [9] Chakrabarti S K, Ghosh S, Banerjee S, et al.Oxidative stress in hypothyroid patients and the role of antioxidant supplementation.Indian J Endocrinol Metab, 6,0(5):674-678.
    [10] Yan Y, Jiang F, Lai Y, et al.Effect of thyrotropin on osteopontin, integrin αvβ3, and VCAM-1 in the endothelium via activation of Akt.Int J Mol Sci, 6,7(9):1 484.
    [11] Bilgir F, Bilgir O, Calan M, et al.Subclinical hypothyroidism:comparison of adhesion molecule levels before and after levothyroxine therapy.J Int Med Res, 4,2(3):806-814.
    [12] Joffe B I, Distiller L A.Diabetes mellitus and hypothyroidism:strange bedfellows or mutual companions？.World J Diab, 4,5(6):901-904.
    [13] Varela L, Martínez-Sánchez N, Gallego R, et al.Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.J Pathol, 2,7(2):209-222.
    [14] Sarfokantanka O, Sarfo F S, Ansah E O, et al.Frequency and determinants of thyroid autoimmunity in Ghanaian type 2 diabetes patients:a case-control study.BMC Endocr Disorders, 7,7(1):2.
    [15] 王文正, 赵素梅, 高士争.Leptin介导的JAK/STAT信号通路对脂类代谢调节的研究进展.中国细胞生物学学报, 1,3(5):584-589.
    [16] Zaid A H, Molham A H, Ali A M, et al.Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus.Diabetol Metab Syndr, 4,6(1):99.
    [17] Wang C.The relationship between type 2 diabetes mellitus and related thyroid diseases.J Diab Res, 3,3(6):390 534.
    [18] Liu F, Yang Q, Gao N, et al.Decreased plasma nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus.J Diab Res, 5,4(1):128 014.
    [19] Gonzalez R, Reingold B K, Gao X, et al.Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells.J Endocr, 1,8(3):R9.
    [20] Tian L, Song Y, Xing M, et al.A novel role for thyroid-stimulating hormone:up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate responsive element binding protein pathway.Hepatology, 0,2(4):1 401-409.
    [21] Triolo M, Kwakernaak A J, Perton F G, et al.Low normal thyroid function enhances plasma cholesteryl ester transfer in type 2 diabetes mellitus.Atherosclerosis, 3,8(2):466-471.
    [22] Ying H, Tang Y P, Bao Y R, et al.Maternal TSH level and TPOAb status in early pregnancy and their relationship to the risk of gestational diabetes mellitus.Endocrine, 6,4(3):742-750.
    [23] Saleheen D, Haycock P C, Zhao W, et al.Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease:a mendelian randomisation analysis.Lancet Diab Endocrinol, 7,5(7):524-533.
    [24] Maranho R C, Carvalho P O, Strunz C C, et al.Lipoprotein (a):Structure, pathophysiology and clinicalimplications.Arquivos Brasileiros De Cardiologia, 4,3(1):76.
    [25] 田利民, 倪菁, 刘静, 等.TSH对血管内皮细胞和平滑肌细胞影响的研究.中华内分泌代谢杂志, 4,0(3):238-244.
    [26] Tian L, Ni J, Guo T, et al.TSH stimulates the proliferation of vascular smooth muscle cells.Endocrine, 4,6(3):651-658.
    [27] Gupta G, Sharma P, Kumar P, et al.Study on subclinical hypothyroidism and its association with various inflammatory markers.J Clin Diagn Res, 5,9(11):BC04.
    [28] 杨继党, 林清原.糖化血红蛋白及高敏C反应蛋白与脑梗死急性期患者颈动脉粥样硬化的关系.中华神经医学杂志, 3,2(3):286-288.
    [29] 白玉婷.氧化应激与心血管疾病关系的研究进展.医学综述, 2,8(2):192-194.
    [30] Mazur P, Sokoowski G, Hubalewska-Dydejczyk A, et al.Prothrombotic alterations in plasma fibrin clot properties in thyroid disorders and their post-treatment modifications.Thrombosis Research, 4,4(2):510-517.
    [31] Kim J H, Park J H, Kim S Y, et al.The mean platelet volume is positively correlated with serum thyrotropin concentrations in a population of healthy subjects and subjects with unsuspected subclinical hypothyroidism.Thyroid, 3,3(1):31-37.
    [32] 肖文, 李仓霞, 薛海龙, 等.急性脑梗死患者血清纤维蛋白原、D-二聚体与颈动脉粥样硬化斑块的相关性研究.中华神经医学杂志, 2,1(3):266-268.
    [33] 吴璇, 肖谦.亚临床甲状腺功能减退症与血压[J/OL].文摘版:医药卫生, 2015, (2):16-17.
    [34] Gerdes A M.Restoration of thyroid hormone balance:a game changer in the treatment of heart failure？.Am J Physiol Heart Circulatory Physiol, 5,8(1):H1.
    [35] Liu D, Jiang F, Shan Z, et al.A cross-sectional survey of relationship between serum TSH level and blood pressure.J Human Hypert, 0,4(2):134.
    [36] 宋长虹.甲状腺功能减退与亚临床甲减症患者氧化应激指标变化分析.中国医学创新, 2,9(27):61-62.
    [37] Liang L B, Zhang M, Huang H J, et al.Blood lipid, glucose and uric acid in people with subclinical hypothyroidism.Sichuan Da Xue Xue Bao Yi Xue Ban, 3,4(6):954-956.
    [38] Jeong I K.Letter:subclinical hypothyroidism is independently associated with microalbuminuria in a cohort of prediabetic egyptian adults .Diabetes Metab J, 4,8(1):83-84.
    [39] Heo K S, Fujiwara K, Abe J I.Glucagon-like peptide-1 and its cardiovascular effects.current atherosclerosis reports, 2,4(5):422-428.
    [40] Oh J Y, Sung Y A, Lee H J.Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in euthyroid young women.Korean J Intern Med, 3,8(2):180.
    [41] Triolo M, de Boer J F, Annema W, et al.Low normal free T4 confers decreased high-density lipoprotein antioxidative functionality in the context of hyperglycaemia.Clin Endocrinol, 3,9(3):416-423.
    Related
    Cited by
Get Citation

DU Hai-Mei, WANG Na, ZHANG Yong-Li. Diabetes mellitus combined with subclinical hypothyroidism and its impact on atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(3):315-320.

Copy
Share
Article Metrics
  • Abstract:1482
  • PDF: 888
  • HTML: 0
  • Cited by: 0
History
  • Received:August 06,2017
  • Revised:November 26,2017
  • Online: April 03,2018
Article QR Code

You are the 57493 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025