Progress of metallothionein 2A in cardiovascular and cerebrovascular diseases

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Progress of metallothionein 2A in cardiovascular and cerebrovascular diseases
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                        DAI Ming-QiangDAI Ming-Qiang
Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China
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JIAO RongJIAO Rong
Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China
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XU Cai-XiaXU Cai-Xia
Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China
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XIE Hui-XingXIE Hui-Xing
Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China
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LI Tian-FaLI Tian-Fa
Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China
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LI Ji-KeLI Ji-Ke
Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China
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Affiliation:Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China)
Clc Number:R54
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Abstract:

Recently, some studies have found that metallothionein 2A (MT2A) is an important antioxidant stress molecule. MT2A gene polymorphism is closely related to coronary heart disease and atherosclerosis. MT2A has the effect of reducing cerebral ischemia-reperfusion injury and protecting the myocardium. The effect of MT2A on cardiovascular and cerebrovascular diseases includes inflammation, oxidative stress, apoptosis and endothelial function. This article reviews the relationship between MT2A and cardiovascular, cerebrovascular diseases.

Key words:Metallothionein 2A; Cardiovascular disease; Cerebrovascular disease; Oxidative stress; Apoptosis

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DAI Ming-Qiang, JIAO Rong, XU Cai-Xia, XIE Hui-Xing, LI Tian-Fa, LI Ji-Ke. Progress of metallothionein 2A in cardiovascular and cerebrovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(3):310-314.

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Received:July 27,2017
Revised:September 18,2017
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Online: April 03,2018
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