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Research progress of the relationship between β3-adrenoceptor and cardiovascular diseases
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Affiliation:

1.Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu, China;2.Department of Cardiology, the People's Hospital of Liyang, Liyang 213300, Jiangsu, China)

Clc Number:

R5

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    Abstract:

    Cardiovascular diseases, such as myocardial infarction, chronic heart failure, are the main causes of human death. It is clear that lipid metabolic dysfunction, diabetes and so on are important risk factors for the occurrence and development of cardiovascular diseases. Changes in myocardial structure, Ca2＋ signaling, cellular metabolism, oxidative stress, activation of renin-angiotensin system and mitochondrial dysfunction are associated with the development of cardiovascular diseases. Since β3-adrenoceptor (β3-AR) has been cloned in 1989, the researchers have found that β3-AR is associated with cardiovascular diseases. β3-AR stimulation can regulate lipid metabolism, improve cardiac function and remodeling, therefore, perhaps prevent and treat cardiovascular diseases.

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ZHANG Zi-Sang, ZHANG Xin-Ru, LI Guang-Yu, ZHANG Jin-Song, DU Rong-Zeng. Research progress of the relationship between β3-adrenoceptor and cardiovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(2):207-212.

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History
  • Received:May 19,2017
  • Revised:July 27,2017
  • Online: March 07,2018
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