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The adipocytokine omentin and its relationship with atherosclerosis
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1. Neurology Department of Xi’an No.3 Hospital, Xi’an, Shaanxi 710018, China;2.The Medicine Institute of Yan’an University, Yan’an, Shaanxi 716000, China)

Clc Number:

R363

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    Abstract:

    The newly found adipocytokine omentin, secreted from visceral fat tissue, is reported to have close revelation with metabolic syndrome and inflammatory diseases with the ability of improving insulin sensitivity. As an independent indicator of the existence of carotid atherosclerosis plaque, omentin might regulate the incidence and development of atherosclerosis. Omentin may play an anti-atherosclerosis role by protecting endothelia cells from injuries, inhibiting the formation of macrophage-derived foam cells, suppressing the proliferation, migration and the secreting of smooth muscle cells, as well as its anti-inflammatory effects. This review mainly goes through the papers in terms of omentin and its relationship with atherosclerosis, which may provide a valuable view of atherosclerosis.

    Reference
    [1] Li Y, Wang DD, Ley SH, et al.Potential impact of time trend of life-style factors on cardiovascular disease burden in China .J Am Coll Cardiol, 6,8(8):818-833.
    [2] Lobato NS, Filgueira FP, Akamine EH, et al.Mechanisms of endothelial dysfunction in obesity-associated hypertension .Braz J Med Biol Res, 2,5(5):392-400.
    [3] Chiricozzi A, Raimondo A, Lembo S, et al.Crosstalk between skin inflammation and adipose tissue-derived products:pathogenic evidence linking psoriasis to increased adiposity .Expert Rev Clin Immuno, 6,2(12):1 299-308.
    [4] McGown C, Birerdinc A, Younossi ZM.Adipose tissue as an endocrine organ .Clin Liver Dis, 4,8(1):41-58.
    [5] Onur I, Oz F, Yildiz S, et al.Serum omentin 1 level is associated with coronary artery disease and its severity in postmenopausal women .Angiology, 4,5(10):896-900.
    [6] Kadoglou NP, Tahmatzidis DK, Giannakoulas C, et al.Serum levels of novel adipokines, omentin-1 and chemerin, in patients with acute myocardial infarction:KOZANI STUDY .J Cardiovasc Med, 5,6(5):341-346.
    [7] Balli U, Bozkurt DS, Ongoz DF, et al.The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy .J Ora Sci, 6,8(4):465-473.
    [8] Shibata R, Takahashi R, Kataoka Y, et al.Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men .Hypertens Res, 1,4(12):1 309-312.
    [9] Yoo HJ, Hwang SY, Hong HC, et al.Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes .Cardiovasc Diabetol, 1,0(1):1-8.
    [10] Schffler A, Neumeier M, Herfarth H, et al.Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue .Biochim Biophys Acta, 6,2(1-3):96-102.
    [11] Pickering RT, Lee MJ, Karastergiou K, et al.Depot dependent effects of dexamethasone on gene expression in human omental and abdominal subcutaneous adipose tissues from obese women .PLoS One, 6,1(12):e0167337.
    [12] Berti L, Hartwig S, Irmler M, et al.Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes:a targeted proteomics approach .Arch Physiol Biochem, 6,2(5):281-288.
    [13] Wesener DA, Wangkanont K, McBride R, et al.Recognition of microbial glycans by human intelectin-1 .Nat Struc Mol Biol, 5,2(8):603-610.
    [14] Zabetiantarghi F, Mirzaei K, Keshavarz SA, et al.Modulatory role of omentin-1 in inflammation:cytokines and dietary intake .J Am Coll Nutr, 6,5(8):670-678.
    [15] Moreno-Navarrete JM, Ortega F, Castro A, et al.Circulating omentin as a novel biomarker of endothelial dysfunction .Obesity, 1,9(8):1 552-559.
    [16] Mazakitovi S, Vaisbuch E, Tarca AL, et al.Characterization of visceral and subcutaneous adipose tissue transcriptome and biological pathways in pregnant and non-pregnant women:evidence for pregnancy-related regional-specific differences in adipose tissue .PLoS One, 5,0(12):e0143 779.
    [17] Chen Q, Shang X, Yuan M, et al.Effect of atorvastatin on serum omentin-1 in patients with coronary artery disease .Coron Artery Dis, 7,8(1):44-51.
    [18] Sperling M, Grzelak T, Pelczyńska M, et al.Concentrations of omentin and vaspin versus insulin resistance in obese individuals .Biomed Pharmacother, 6,3:542-547.
    [19] Berstein LM, Iyevleva AG, Mukhina MS, et al.Features of omental adipose tissue in endometrial cancer patients with ‘standard’ or ‘metabolically healthy’ obesity:associations with tumor process characteristics .Springerplus, 6,5(1):1 900-907.
    [20] Guvenc Y, Var A, Goker A, et al.Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome .J Int Med Res, 6,4(4):796-805.
    [21] Shibata R, Ouchi N, Takahashi R, et al.Omentin as a novel biomarker of metabolic risk factors .Diabetol Metab Syndr, 2,4(1):37-40.
    [22] Bremer AA, Jialal I.Adipose tissue dysfunction in nascent metabolic syndrome.J Obes, 3,3:393192.
    [23] Watanabe K, Watanabe R, Konii H, et al.Counteractive effects of omentin-1 against atherogenesis .Cardiovasc Res, 6,0(1):118-128.
    [24] Robinson C, Tsang L, Solomon A, et al.Omentin concentrations are independently associated with those of matrix metalloproteinase-3 in patients with mild but not severe rheumatoid arthritis .Rheumatol Int, 6,7(1):3-11.
    [25] Ross R.Atherosclerosis:an inflammatory disease .N Eng J Med, 9,0(2):115-126.
    [26] Ross R.The pathogenesis of atherosclerosis:a perspective for the 1990s .Nature, 3,2(6423):801-809.
    [27] Kadoglou NP, Lambadiari V, Gastounioti A, et al.The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability .Atherosclerosis, 4,5(2):606-612.
    [28] Uemura Y, Shibata R, Kanemura N, et al.Adipose-derived protein omentin prevents neointimal formation after arterial injury .FASEB J, 5,9(1):141-151.
    [29] Gimbrone MA Jr, Garcia-Cardena G.Endothelial cell dysfunction and the pathobiology of atherosclerosis .Circ Res, 6,8(4):620-636.
    [30] Harada K, Shibata R, Ouchi N, et al.Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients .Atherosclerosis, 6,1:299-304.
    [31] Maruyama S, Shibata R, Kikuchi R, et al.Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism .J Biol Chem, 2,7(1):408-417.
    [32] Naito C, Hashimoto M, Watanabe K, et al.Facilitatory effects of fetuin-A on atherosclerosis .Atherosclerosis, 6,6(13):344-351.
    [33] Hiramatsu-Ito M, Shibata R, Ohashi K, et al.Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice .Cardiovasc Res, 6,0(1):107-117.
    [34] Kazama K, Usui T, Okada M, et al.Omentin plays an anti-inflammatory role through inhibition of TNF-alpha-induced superoxide production in vascular smooth muscle cells .Eur J Pharmacol, 2,6(1-3):116-123.
    [35] Chen X, An X, Chen D, et al.Chronic exercise training improved aortic endothelial and mitochondrial function via an AMPKα2-dependent manner .Front Physiol, 6,7(3):631-640.
    [36] Jenkinson SE, Brown LJ, Ombor J, et al.Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function .Biochim Biophys Acta, 7,4(2):336-344.
    [37] Yamawaki H, Kuramoto J, Kameshima S, et al.Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells .Biochem Biophys Res Commun, 1,8(2):339-343.
    [38] Zhong X, Li X, Liu F, et al.Omentin inhibits TNF-alpha-induced expression of adhesion molecules in endothelial cells via ERK/NF-kappaB pathway .Biochem Biophys Commun, 2,5(2):401-406.
    [39] Shibata R, Ouchi N, Kikuchi R, et al.Circulating omentin is associated with coronary artery disease in men .Atherosclerosis, 1,9(2):811-814.
    [40] Menzel J, di Giuseppe R, Biemann R, et al.Omentin-1 and risk of myocardial infarction and stroke:results from the EPIC-Potsdam cohort study .Atherosclerosis, 6,1:415-421.
    [41] Saely CH, Leiherer A, Muendlein A, et al.Coronary patients with high plasma omentin are at a higher cardiovascular risk .Data Brief, 6,6:158-161.
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GAO Li-Jie, LI Bin, SHI Wen-Zhen, CHEN Xia, HAN Nan-Nan, ZHU Xu-Rong, WANG Tian-Zhong, SHI Huan-Huan, ZHAO Ning, TIAN Ye. The adipocytokine omentin and its relationship with atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(11):1179-1183.

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History
  • Received:March 14,2017
  • Revised:May 18,2017
  • Online: November 28,2017
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