The newly found adipocytokine omentin, secreted from visceral fat tissue, is reported to have close revelation with metabolic syndrome and inflammatory diseases with the ability of improving insulin sensitivity. As an independent indicator of the existence of carotid atherosclerosis plaque, omentin might regulate the incidence and development of atherosclerosis. Omentin may play an anti-atherosclerosis role by protecting endothelia cells from injuries, inhibiting the formation of macrophage-derived foam cells, suppressing the proliferation, migration and the secreting of smooth muscle cells, as well as its anti-inflammatory effects. This review mainly goes through the papers in terms of omentin and its relationship with atherosclerosis, which may provide a valuable view of atherosclerosis.