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Association of interleukin-6 gene －572C/G polymorphism with combined hyperlipidemia of the Han Nationality in Zunyi
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1.Clinical Laboratory, Affiliated Hospital of Zunyi Medical College, ;2.Medical Genetics Department, ;3.Grade 2012, Department of Clinical Medicine, ;4.Grade 2010, Department of Medical Laboratory, Zunyi Medical College, Zunyi,Guizhou 563099, China)

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R5

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    Abstract:

    Aim To investigate the relativity of interleukin-6 gene－572C/G polymorphism with combined hyperlipidemia in Zunyi Han Nationality. Methods －572C/G polymorphism of 100 combined hyperlipidemia patients and 100 healthy individuals were tested by sequencing after polymerase chain reaction. Results Age, gender and blood sugar had no statistical differences between patients group and normal group, but blood lipid index of combined hyperlipidemia patients was higher than healthy individuals(P<0.05). The genotype frequency and allele gene frequency of IL-6 gene －572C/G showed no correlation between patients group and normal groups (P>0.05). Total cholesterol (TC), low density lipoprotein cholesterol (LDLC), triglyceride(TG)/high density lipoprotein cholesterol (HDLC) and TC/HDLC were different between CC and CG+GG genotype in the normal group(P<0.05); others had no differences among the two groups. Conclusion There was no relativity between IL-6 gene －572C/G polymorphism and combined hyperlipidemia in Zunyi Han Nationality. The －572G gene was not an independent risk factor for combined hyperlipidemia.

    Reference
    [1] 中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南.中华心血管病杂志, 7,5(5):390-419.
    [2] 张沛然, 郭改会.高脂血症的发病机制及分类.中国临床医生杂志, 2,0(3):18-20.
    [3] 郭艺芳.2014年中国胆固醇教育计划血脂异常防治专家建议.中华心血管病杂志, 4,2(3):3-5.
    [4] 何美霞, 张明明, 刘琼, 等.白细胞介素-6基因多态性与高脂血症的相关性.中国老年学杂志, 1,1(1):23-25.
    [5] Yan D, Zhu M A, Zhi X W, et al.Associations of polymorphisms in the apolipoprotein APOA1-C3-A5gene cluster with acute coronary syndrome.J Biomed Biotechnol, 2,2(1):1-5.
    [6] 肖代敏, 耿争光, 杨昌伟, 等.遵义汉族人群载脂蛋白A5基因多态性与高胆固醇血症的关系.中国动脉硬化杂志, 7,5(5):485-489.
    [7] Xu Jiao-xia, Xiang Hui, Xiong Wen, et al.The study on the correlation of the low density lipoprotein receptor gene polymorphism with essential hypertension.Guide Chin Med, 3,2:5-6.
    [8] 刘东芳, 张宝琴, 张振宇, 等.唐山地区汉族人群急性脑梗死患者IL-6基因-174G/C和－572C/G多态性.中国老年学杂志, 2,2(23):5 125-126.
    [9] 梁振洋, 张笑林, 孙莹, 等.北方汉族人群白细胞介素-6基因－572C/G单核苷酸多态性与冠心病的相关性研究.现代生物医学进展, 0,0(24):4 675-678.
    [10] 陈丹, 张葵, 魏红霞, 等.IL-6基因－572C/G多态性与江苏宿迁地区汉族人群冠心病的关系.临床检验杂志, 6,4(5):366-370.
    [11] 赵卫新, 苏国生.白细胞介素6在心脑血管疾病中的临床应用新进展.中国实用医药, 2,7(15):244-245.
    [12] 张玉领, 陈培, 王季茹, 等.白介素6基因多态性与2型糖尿病相关性的Meta分析.中国糖尿病杂志, 4,2(1):16-20.
    [13] 何美霞, 张明明, 刘琼, 等.白细胞介素-6基因多态性与高脂血症的相关性.中国老年学杂志, 1,1(1):23-25.
    [14] Younis S, Javed Q.The interleukin-6 and interleukin-1A gene promoter polymorphism os associated with the pathogenesis of acne vulgaris.Arch Dermatol Res, 5,7:365-370.
    [15] Wang M, Jia J.The interleukin-6 gene －572C/G promoter polymorphism modifiers Alzheimer’s risk in APOE ε4 carriers.Neuroscience Letters, 0,2(3):260-263.
    [16] Yuan A, Li J, Liu P, et al.Association of interleukin-6 －572C/G gene polymorphism and serum or cerebrospinal fluid interleukin-6 level with enterovirus 71 encephalitis in chinese han patients with hand, foot, and mouth disease.Inflammation, 5,8(2):728-735.
    [17] Greene C M, Zern T L, Wood R J, et al.Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge .J Nut, 5,5(12):2 793-798.
    [18] Elshazly MB, Quispe R, Michos ED, et al.Patient-level discordance in population percentiles of the TC/HDL-C ratio compared with LDL-C and Non-HDL-C:the Very Large Database of Lipids Study (VLDL-2B).Circulation, 5,2(8):667-676.
    [19] 李莹, 陈志红, 周北凡, 等.我国中年人群血清TC/HDL-C比值与缺血性和出血性脑卒中发病危险性.中华神经科杂志, 5,8(5):305-308.
    [20] 李明春, 初少莉, 左君丽, 等.LDL-C/HDL-C与冠状动脉病变程度的相关性研究.第二军医大学学报, 4,5(3):270-273.
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LV Chun-Li, ZHANG Zhi-Min, GENG Zheng-Guang, YANG Chang-Wei, XIAO Dai-Min. Association of interleukin-6 gene －572C/G polymorphism with combined hyperlipidemia of the Han Nationality in Zunyi[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(9):904-908.

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History
  • Received:August 09,2017
  • Revised:September 06,2017
  • Online: September 29,2017
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