Genetic researches of atrial fibrillation (AF) include the following topics which are important in clinical practice:①the molecular genetic variations of mono/polygenic AF; ②the reasonable classification of AF based on genetics; ③the underlying genetic reasons of its familial segregation; ④the impact of genotype difference on prognosis of patients with AF and AF risk prediction; ⑤the genetic studies on AF treatment. This review is an update on the above-mentioned issues.