Aim To study the effects of Xin Tong-tai (XTT) on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and interleukin 6 (IL-6), and aortic tissue high-sensitivity C-reactive protein (hs-CRP) and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) in atherosclerotic rabbits. Methods A total of 120 healthy Japanese rabbits were randomly divided into control group, model group, low-dose XTT group, middle-dose XTT group, high-dose XTT group and rosuvastatin group. In this prospective study, the drug intervention groups were treated with the corresponding drugs at the same time. After 60 days, serum levels of Lp-PLA2 and IL-6 were measured; The contents of hs-CRP and LOX-1 in thoracic aorta were detected by immunohistochemistry method. Results The serum levels of Lp-PLA2 and IL-6 in low-dose XTT group, middle-dose XTT group and high-dose XTT group were lower than those in model group (P＜0.01). Compared with low-dose XTT group, the serum levels of Lp-PLA2 and IL-6 were decreased in middle-dose XTT group, high-dose XTT group and rosuvastatin group (P＜0.01 or P＜0.05). The expression levels of hs-CRP and LOX-1 in middle-dose XTT group and high-dose XTT group were lower than those in model group (P＜0.01). Compared with low-dose XTT group, the expression levels of hs-CRP and LOX-1 were decreased in middle-dose XTT group, high-dose XTT group and rosuvastatin group (P＜0.05). Immunohistochemical staining showed that in model group, there was a large amount of hs-CRP and LOX-1 expression in aortic intima; Compared with model group, the expressions of hs-CRP and LOX-1 in the aorta were reduced in low-dose XTT group, middle-dose XTT group, high-dose XTT group and rosuvastatin group. Conclusion Xin Tong-tai can decrease the levels of Lp-PLA2, IL-6, hs-CRP and LOX-1 in atherosclerotic rabbits, so as to achieve the effect of reducing atherosclerosis inflammatory reaction.