2025年5月25日 周日
Home > Archive>Volume 25, Issue 7, 2017 >741-745
PDF HTML XML Export Cite reminder
The roles of sphingosine-1-phosphate receptor 3 in cardiovascular system
Author:
Affiliation:

1.Department of Cardiothoracic Surgery, ;2.Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, China)

Clc Number:

R5

  • Article
    • | |
  • Metrics
    • |
  • Reference [25]
    • | | | |
  • Comments
    Abstract:

    Sphingosine-1-phosphate receptors are important targets for sphingosine-1-phosphate to play roles in cells, and five subtypes of sphingosine-1-phosphate receptors are included, which are widely expressed in all systems including cardiovascular system. The receptors have various important biological effects on vasodilatation, vascular endothelial barrier function, ischemia reperfusion injury, atherosclerosis, etc. This paper makes a review on roles and mechanisms of sphingosine-1-phosphate receptor 3 in cardiovascular system.

    Reference
    [1] 郭守东, 于杨, 冯蕾, 等.液-质联用法对生物样本中鞘氨醇1-磷酸的微量测定.中国动脉硬化杂志, 3,1(4):354-358.
    [2] Ishii I, Fukushima N, Ye X, et al.Lysophospholipid receptors:signaling and biology.Annu Rev Biochem, 4,3:321-354.
    [3] Kono M, Mi Y, Liu Y, et al.The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis.J Biol Chem, 4,9(28):29 367-373.
    [4] Yu M, Zhang H, Liu Y, et al.The cooperative role of S1P3 with LYVE-1 in LMW-HA-induced lymphangiogenesis.Exp Cell Res, 5,6(1):150-157.
    [5] Filipenko I, Schwalm S, Reali L, et al.Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation.Biochim Biophys Acta, 6,1(11):1 840-851.
    [6] Ruiz M, Okada H, Dahlback B.HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium.Lipids Health Dis, 7,6(1):36.
    [7] Tlle M, Klockl L, Wiedon A, et al.Regulation of endothelial nitric oxide synthase activation in endothelial cells by S1P1 and S1P3.Biochem Biophys Res Commun, 6,6(4):627-634.
    [8] Cheng H , Chen Y , Wong J , et al.Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway.J Exp Clin Cancer Res, 7,6(1):27.
    [9] Machida T, Matamura R, Iizuka K, et al.Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate.J Pharmacol Sci, 6,2(4):211-217.
    [10] Murakami A, Takasugi H, Ohnuma S, et al.Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor:investigation based on a new S1P3 receptor antagonist.Mol Pharmacol, 0,7(4):704-713.
    [11] Takuwa N, Ohkura S, Takashima S, et al.S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.Cardiovasc Res, 0,5(3):484-493.
    [12] Yung B, Brand C, Xiang S, et al.Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection.J Mol Cell Cardiol, 7,3:1-10.
    [13] Zhu C, Cao C, Dai L, et al.Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells.Vascul Pharmacol, 5,1:116-126.
    [14] 黄海涛, 李星, 王亮, 等.S1PR2和S1PR3通路激活Rac1参与HGF诱导的血管内皮屏障保护作用.解剖科学进展, 5,1(4):383-385.
    [15] Sammani S, Moreno-Vinasco L, Mirzapoiazova T, et al.Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.Am J Respir Cell Mol Biol, 0,3(4):394-402.
    [16] Lin C, Lee I, Hsu C, et al.Sphi湮楧??偩??吭愱礭汰潨牯?????敥琠?慥汤?卡灴桥楳渠杉潃獁楍渭攱???灰桥潮獤灥桮慴琠敭?敮汯楣捹楴瑥猠?剤桨潥??摯敮瀠整湨摲敯湵瑧?瀠牰漳永椠晍敁牐態琠楡潮湤?慰渴搲??刴吴????测攭摤楥慰瑥敮摤?杮整渠敁?楴渠摡畣捴瑩楶潡湴?楯湮??偌?獓??敮汥氬?匵椬朰渨愳氩??????????????????戱爷????孪??崠?圬愠湍条?????甠?????楺畵?奡??攬琠?慴氠??吮奓??ど?慧瑯瑳敩湮略愠琱攭獰?桯祳灰潨硡楴慥?物敮潣硲祥条敳湥慳琠楡潮渠?楮湴摲畡捣敥摬?慵灬潡灲琠潃獡椼獳?楰渾′挫愼爯摳極潰派祣潯据祣瑥敮獴??硴灩??漠汶?偡愠瑓栱潐氳?????????㈠????????扲牥????孳??嵬??愠浳浭?????汭慵?呣???慣步獬桬楳?削??敨瑡?慭氠??慡牲摭楡慣捯?愬渠搴?瘶愨猶挩町永愰爲?攸昱昰攮挼瑢獲￣漊昊?晛椱游杝漠汄楥浳潡摩?浐攬挠桓慴湥楩獮琠楊捊?戠慓獩楤獤?慱湵摩?捓汁椬渠楥捴愠污?椮浄灹汳楬捩慰瑩楤潥湭獩??浲??敵慬牡瑴????????????????????扩牮????扤爠?ascular smooth muscle cell chemotaxis.Mol Cell Biochem, 5,0(1-2):85-91.
    [19] Shimizu T, De Wispelaere A, Winkler M, et al.Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries.Arterioscler Thromb Vasc Biol, 2,2(4):955-961.
    [20] Keul P, Lucke S, Von Wnuck Lipinski K, et al.Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis.Circ Res, 0,8(3):314-323.
    [21] Vargas WS, Perumal JS.Fingolimod and cardiac risk:latest findings and clinical implications .Ther Adv Drug Saf, 3,4(3):119-124.
    [22] Sanna M, Vincent K, Repetto E, et al.Bitopic sphingosine 1-phosphate receptor 3 (S1P3) antagonist rescue from complete heart block:pharmacological and genetic evidence for direct S1P3 regulation of mouse cardiac conduction.Mol Pharmacol, 6,9(1):176-186.
    [23] Zhang G, Liang Z, Zhang X.Sphingosine-1-phosphate receptors respond differently to early myocardial ischemia and ischemia-reperfusion in vivo.Sheng Li Xue Bao, 4,6(2):169-174.
    [24] Morel S, Christoffersen C, Axelsen LN, et al.Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein connexin43.Cardiovasc Res, 6,9(3):385-396.
    [25] 刘晔弘, 范骎, 张凤如, 等.S1P受体激动剂FTY720在大鼠非梗死区心肌组织中的作用.上海交通大学学报(医学版), 6,6(9):1 271-277.
    [26] Bajwa A, Huang L, Kurmaeva E, et al.Sphingosine 1-phosphate receptor 3-deficient dendritic cells modulate splenic responses to ischemia-reperfusion injury.J Am Soc Nephrol, 6,7(4):1 076-090.
    [27] Castaldi A, Chesi
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

HAO Bo, LUO Guang-Hua, ZHANG Xiao-Ying, DI Dong-Mei. The roles of sphingosine-1-phosphate receptor 3 in cardiovascular system[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(7):741-745.

Copy
Share
Article Metrics
  • Abstract:870
  • PDF: 978
  • HTML: 0
  • Cited by: 0
History
  • Received:February 22,2017
  • Revised:April 29,2017
  • Online: July 31,2017
Article QR Code

You are the 48701 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025