It has been widely accepted that atherosclerosis is a chronic inflammatory disease of blood vessels, and immune cells play an important role in atherosclerosis, but the specific mechanism of the inflammatory immune factors still need more comprehensive and in-depth discussion. With the development of technology,the importance of glycobiology in immune response has been found. Among them, sialic acid binding immunoglobulin-like lectin (Siglec) families is closely related to inflammatory immune cells and have higher species-specific. Siglec-1,5 and 7 are associated with the activity of monocyte and macrophage, Siglec-2 and 10 modulate the activity of B lymphocyte, Siglec-5,9 and 14 are associated with the activity of neutrophil. It is indicated that Siglec may take part in the formation of atherosclerosis through regulating the activity of immune cells. Although there is few direct evidence supporting the hypothesis, studies have shown that inhibition of Siglec-1 expression can attenuate atherogenesis in ApoE-deficient mice. The study tries to explore new mechanism of inflammatory immune factors in atherosclerosis and new potential targets to prevent the atherosclerosis through the perspective of glycobiology. Therefore, it discusses the advances in the relationship between Siglec and atherosclerosis associated immune cells.