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Advances in the regulation of lipoprotein lipase in various tissues
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1.Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Human Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, ;2.School of Pharmacy and Life Science, University of South China, Hengyang, Hunan 421001, China)

Clc Number:

R363

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    Abstract:

    Adipose tissue lipoprotein lipase (LPL) is regulated by angiopoietin-like protein and influences the storage and energy supply of adipose energy. Myocardial LPL is regulated by peroxisome proliferator-activated receptor and adenosine monophosphate activated protein kinase and influences the uptake of free fatty acids in the absence of cardiac energy supply. Macrophage LPL is regulated by microRNA and inhibits the formation of foam cells. The regulation of LPL in various tissues is influenced by many factors, and the effects are different. In this paper, we reviewed the regulation of LPL in adipose tissue, myocardium and macrophages, and the effects of related proteins on LPL activity, in order to further clarify the role and significance of LPL in various tissues.

    Reference
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ZHANG Xin, WANG Zong-Bao, TANG Chao-Ke. Advances in the regulation of lipoprotein lipase in various tissues[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(6):630-634.

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History
  • Received:December 26,2016
  • Revised:February 23,2017
  • Online: June 05,2017
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