Relations between growth differentiation factor-15 and no-reflow in patients with acute myocardial infraction

Home > Archive>Volume 25, Issue 6, 2017 >599-603

Relations between growth differentiation factor-15 and no-reflow in patients with acute myocardial infraction
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                        SUN LingSUN Ling
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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ZANG XuanZANG Xuan
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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ZHANG Liang-FengZHANG Liang-Feng
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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SONG YingSONG Ying
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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CHEN XinCHEN Xin
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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LI Hai-YanLI Hai-Yan
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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WANG XinWANG Xin
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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WANG Qing-JieWANG Qing-Jie
Department of Cardiology, Changzhou No.2 Peoples Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China
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Affiliation:Department of Cardiology, Changzhou No.2 People's Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China)
Clc Number:R5
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Abstract:

Aim To evaluate the effect of growth differentiation factor-15 (GDF-15) in predicting no-reflow in patients with acute myocardial infraction (AMI) undergoing percutaneous coronary intervention (PCI). Methods Totally 243 consecutive patients with AMI were enrolled and serum GDF-15 levels were measured within 24 hours. All patients were divided into two groups according to the occurrence of no-reflow during PCI. Results There were 44 patients in no-reflow group (average age was 67.00±13.04 ) and 199 patients in normal-reflow group (average age was 65.54±12.98). The serum GDF-15 levels increased in no-reflow group (1073.43±364.38 ng/L vs 714.10±340.98 ng/L, P<0.001). The area under the receiver operating characteristic curves (AUC) was 0.829 (95%CI:0.766～0.892). Logistic regression showed that GDF-15 (OR:1.3,5% CI:1.001～1.004, P＜0.001) and female (OR:2.6,5%CI:1.358～6.610, P=0.007) were independent risk factors for no-reflow during PCI in AMI patients. Conclusion GDF-15 and female were independent risk factors for no-reflow during PCI in AMI patients.

Key words:Acute myocardial infraction; Percutaneous coronary intervention; Growth differentiation factor-15;No-reflow

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SUN Ling, ZANG Xuan, ZHANG Liang-Feng, SONG Ying, CHEN Xin, LI Hai-Yan, WANG Xin, WANG Qing-Jie. Relations between growth differentiation factor-15 and no-reflow in patients with acute myocardial infraction[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(6):599-603.

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Received:February 19,2017
Revised:May 02,2017
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Online: June 05,2017
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