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Expression and significance of the miRNAs target to PPARγ in coronary artery in-stent restenosis
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Affiliation:

1. Department of Cardiology, ;2. Department of Cardiac Surgery, ;3. Shandong Provinicial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, China)

Clc Number:

R542.2

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    Abstract:

    Aim To explore the key members of the miRNAs target to peroxisome proliferator-activated receptor γ(PPARγ), and reveal the clinical significance of which are closely related to in-stent restenosis(ISR). Methods Cytoscape and its plug-in was used to build the miRNAs-PPAR regulatory network to screen out which are the key miRNAs target to PPARγ. The expression of miRNAs in ISR group were detected by Real-time PCR and the clinical recognition ability of miRNAs on ISR patients were evaluated by ROC curve. Results By bioinformatics analysis, miR-27a/b has a strong regulatory effect on PPARγ, while miR-130a/b is able to regulate more genes in the network. Real-time PCR found that miR-27a/b and miR-130a were differentially expressed in the ISR group and no-ISR group (P<0.05). ROC curve analysis showed that miR-27a has a certain clinical recognition ability to ISR (AUC =0.4,5% CI 0.768~1.00, P<0.001). Conclusion MiR-27a/b and miR-130a/b are key members of the miRNAs target to PPARγ, miR-27a/b and miR-130a were differentially expressed in ISR, miR-27a might have certain clinical diagnostic value in patients with ISR.

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ZHANG Shao-Hui, ZHAO Yong-Liang, WEI Guang-He, LIU Li-Xin, YANG Guo-Liang, GAO Zhen-Cai, LIN Yue-Dong, GUO Ying. Expression and significance of the miRNAs target to PPARγ in coronary artery in-stent restenosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(6):582-589.

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History
  • Received:October 11,2016
  • Revised:January 19,2017
  • Online: June 05,2017
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