Lipoprotein lipase degradation and metabolic disorders

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Lipoprotein lipase degradation and metabolic disorders
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                        CHENG Hai-PengCHENG Hai-Peng
Institute of Cardiovascular Disease, University of South China & Key Laboratory for Atherosclerology of Hunan Province & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Medical Research Center, University of South China, Hengyang, Hunan 421001, China
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YIN Wei-DongYIN Wei-Dong
Institute of Cardiovascular Disease, University of South China & Key Laboratory for Atherosclerology of Hunan Province & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Medical Research Center, University of South China, Hengyang, Hunan 421001, China
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TANG Chao-KeTANG Chao-Ke
Institute of Cardiovascular Disease, University of South China & Key Laboratory for Atherosclerology of Hunan Province & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Medical Research Center, University of South China, Hengyang, Hunan 421001, China
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Affiliation:Institute of Cardiovascular Disease, University of South China & Key Laboratory for Atherosclerology of Hunan Province & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Medical Research Center, University of South China, Hengyang, Hunan 421001, China)
Clc Number:R363
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Abstract:

Lipoprotein lipase (LPL) degradation is one of the important ways to regulate the level of LPL. Recently, it has been found that LPL degradation is regulated by a variety of related proteins, the process of LPL degradation mainly includes two parts:intracellular degradation and extracellular degradation. The intracellular degradation of LPL means a large amount of newborn LPL which were transferred to the lysosome for degradation via the related proteins. The extracellular degradation of LPL means mature LPL which were re-uptaked or transported into the cell under the action of the related proteins, and then gathered into lysosomal for degradation. This article will review the LPL in the process of LPL protein synthesis, transportation and biological functions, and then elucidate the relationship between its degradation and metabolic syndrome.

Key words:Lipoprotein lipase; Lysosomes degradation; Atherosclerosis; Diabetic cardiomyopathy; Obesity

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CHENG Hai-Peng, YIN Wei-Dong, TANG Chao-Ke. Lipoprotein lipase degradation and metabolic disorders[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(5):513-518.

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Received:December 26,2016
Revised:February 20,2017
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Online: May 27,2017
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