Exosome provides a new intervention target for atherosclerosis

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Exosome provides a new intervention target for atherosclerosis
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                        JIANG YueJIANG Yue
Institute of Cardiovascular Disease Research & Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China
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TIAN Meng-XiangTIAN Meng-Xiang
Institute of Cardiovascular Disease Research & Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China
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WANG ShuangWANG Shuang
Institute of Cardiovascular Disease Research & Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China
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YI Guang-HuiYI Guang-Hui
Institute of Cardiovascular Disease Research & Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China
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Affiliation:Institute of Cardiovascular Disease Research & Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China)
Clc Number:R363
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Abstract:

Atherosclerosis is a chronic inflammatory disease. The objective of the clinical use of anti-atherosclerotic drugs is to decrease circulating low density lipoprotein level, increase high density lipoprotein level, and reduce inflammation. However, the morbidity and mortality of cardiovascular disease remain high. Therefore, the identification of unknown therapeutic targets and the development of new anti-atherosclerotic drugs is growing. Exosome is a kind of membrane vesicles derived from late nuclear endosome (also known as polycystic body) secreted by living cells. Exosome contains protein, rRNA, and micro RNA, which are related to the source cells, and it can pass the biological barrier and produce various biological functions. Exosome is expected to become a novel drug delivery pathway and gene therapy vector for the treatment of atherosclerosis.

Key words:Exosome; Atherosclerosis; Micro RNA

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JIANG Yue, TIAN Meng-Xiang, WANG Shuang, YI Guang-Hui. Exosome provides a new intervention target for atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(4):411-416.

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Received:September 17,2016
Revised:November 03,2016
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Online: May 18,2017
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