Sirt1 and glucose homeostasis

Home > Archive>Volume 25, Issue 2, 2017 >191-196

Sirt1 and glucose homeostasis
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                        ZHANG Li1ZHANG Li
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China
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YNAG Yong-Yu2YNAG Yong-Yu
Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
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ZHANG Zheng1ZHANG Zheng
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China
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HU Chang-Ping1HU Chang-Ping
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China
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Affiliation:1.Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China;2.Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China)
Clc Number:R563
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Abstract:

Sustained hyperglycemia is the basic feature of insulin resistance and type 2 diabetes. Disorders of glucose homeostasis lead to metabolic dysfunction, thus provoking diabetes and diabetic complications. Sirtuin 1 (Sirt1), a mammalian NAD-dependent protein deacetylase, plays a critical role in energy metabolism and insulin resistance. Recent studies suggest that activation of Sirt1 deacetylates various proteins such as PGC-1α, NF-κB, Foxo1 and Akt, which in turn protects pancreatic β cell functions, improves insulin sensitivity, attenuates inflammation and subsequently maintains glucose homeostasis. This review summarizes recent advances in the role of Sirt1 in regulating glucose homeostasis.

Key words:Sirt 1; Glucose homeostasis; Pancreatic β cells; Insulin sensitivity

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ZHANG Li, YNAG Yong-Yu, ZHANG Zheng, HU Chang-Ping. Sirt1 and glucose homeostasis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2017,25(2):191-196.

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Received:February 25,2016
Revised:June 01,2016
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Online: February 08,2017
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