Aim To investigate the dynamic changes of circulating endothelial progenitor cells(EPC) counts after percutaneous coronary intervention(PCI) in patients with chronic stable angina pectoris and related factors of CD34⁺/KDR⁺ maximum motivation. Methods 93 patients were divided into PCI group (n=72) and control group (n=21).Blood samples were collected by femoral artery sheath or median cubital vein. EPC counts were measured following CAG(baseline) and 1 h, 3 h, 5 h, 7 h, 24 h after PCI or CAG by flow cytometry. Results Population means of different type EPC counts has significantly statistic difference at different time points and EPC counts between PCI group and control group(P＜0.05). In PCI group, CD34⁺/KDR⁺ at 24 h, CD133-/CD34⁺/KDR⁺ at 3 h, 5 h, 24 h, CD133⁺/CD34⁺/KDR⁺ at 5 h, 7 h, CD133⁺/KDR⁺ at 3 h, 5 h, CD133⁺/CD34⁺ at 24 h has significantly statisitc difference compared with baseline(P＜0.05). However, there has no significantly statisitc difference in the counts of each type of EPC at different time points compared with baseline in the control group(P＞0.05). The maximum motivation of CD34⁺/KDR⁺ has negative relationship with basal C-reactive protein, and has positive correlations with body mass index (BMI), angiotensin-converting enzyme inhibitor (ACEI) or angiotensin Ⅱ receptor antagonists (ARB) drug treatment and the quantitative parameters of endothelial injury. Conclusion PCI can initiate time-dependment mobilization of EPC and promote motivation, migration and recruitment of CD34⁺/KDR⁺ which can accelerate endothelial damage reparation and reduce complication of patients with chronic stable angina pectoris after PCI to improve prognosis.