Progress of Research on the Relationship of the Mechanism of Action Between Osteoporosis and Atherosclerosis in OPG/RANK/RANKL Pathway

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Progress of Research on the Relationship of the Mechanism of Action Between Osteoporosis and Atherosclerosis in OPG/RANK/RANKL Pathway
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                        ZHAO Xi-Yun1ZHAO Xi-Yun
Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
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ZHANG Xiao-Gang1,2ZHANG Xiao-Gang
Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China;Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730020, China
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SONG Min1SONG Min
Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
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CAO Lin-Zhong1CAO Lin-Zhong
Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
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ZHANG Hong-Wei1ZHANG Hong-Wei
Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
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WANG Zhi-Peng1WANG Zhi-Peng
Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
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QIN Da-Ping1QIN Da-Ping
Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
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Affiliation:1.Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China;2.Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730020, China)
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Abstract:

Osteoporosis and atherosclerosis are very common diseases associated with elder patients, it has higher incidence rate and more complications, they are the major risk factor for increased mortality. With the increasing of the patient’s age, the clinical connections between them have become increasingly closer. In recent years, OPG/RANKL/RANK pathway is the research high lights and it is a milestone in the research history of osteoporosis. The researchers come to realize that this signal pathway also played an invaluable role in atherosclerosis, enabling researchers conduct extensive research potential between the system and atherosclerosis. This article is about OPG/RANKL/RANK pathway as a bridge connection between them, exploring their common pathogenesis and clinical relationships, for providing further integrated concept in clinical work with these molecules as targets for designing and generating new drugs.

Key words:Osteoprotegerin; Receptor Activator of NF-κB; Receptor Activator of NF-κB Ligand; Osteoporosis; Atherosclerosis

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ZHAO Xi-Yun, ZHANG Xiao-Gang, SONG Min, CAO Lin-Zhong, ZHANG Hong-Wei, WANG Zhi-Peng, QIN Da-Ping. Progress of Research on the Relationship of the Mechanism of Action Between Osteoporosis and Atherosclerosis in OPG/RANK/RANKL Pathway[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(12):1273-1278.

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Received:January 05,2016
Revised:April 04,2016
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Online: February 09,2017
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