mTOR is a serine/threonine kinase, mainly involved in two kinds of signal pathway in regulation. mTOR signaling pathway can regulate cell growth, proliferation and apoptosis. While the mTOR can regulate the process of atherosclerosic development about endothelial cells migration and proliferation, macrophage autophagy, smooth muscle cells proliferation and migration. By inhibiting or activating mTOR in different periods, the vulnerable plaque of atherosclerosis can be stabilized and the development of atherosclerosis can be prevented. mTOR signaling pathway plays a multifaceted effect in atherosclerosis progression. This paper mainly review the relationship of mTOR signaling pathway and atherosclerosis. It provides a new direction for the clinical treatment.