2025年5月21日 周三
Home > Archive>Volume 24, Issue 12, 2016 >1238-1242
PDF HTML XML Export Cite reminder
The Screening and the Functional Pathway Analysis of Differential Genes in Patients with Coronary Heart Disease in Uygur, Kazakh, and Han Population of Xinjiang
Author:
Affiliation:

1.Department of Geriatrics, the Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China;2.Heart Center of the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China;3.Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang 830011, China)

Clc Number:

Q343

  • Article
    • | |
  • Metrics
    • |
  • Reference [8]
    • | | | |
  • Comments
    Abstract:

    Aim To sreen differential genes associated with coronary heart disease in Uygur, Kazakh, and Han population of Xinjiang using gene microarray expression profiles. Methods A case-control study including 9 cases (3 cases in Uygurs, 3 cases in Kazakhs, and 3 cases in Hans) with coronary heart disease confirmed by coronary angiography and 9 gender-, age-, and ethnic-matched normal controls was designed for the present study. Human whole genome expression microarray was used to screen differential genes associated with coronary heart disease. Results 33 genes associated with coronary heart disease were differentially expressed, 26 genes associated with coronary heart disease in Han population were differentially expressed, 2 genes associated with coronary heart disease in Uygur population were differentially expressed, while the differentially expressed genes were not screened in Kazakh population. Through GO and Pathway analysis, the differentially expressed genes were related to immune response. Conclusion The results of gene microarray screening showed that the differentially expressed genes were mainly related to immune response.

    Reference
    [1] Bahri R, Esteban E, Moral P, et al.Apolipoprotein gene polymorphisms and plasma levels in healthy Tunisians and patients with coronary artery disease.Lipids Health Dis, 8,7 (7):46.
    [2] Irizarry RA, Hobbs B, Collin F, et al.Exploration, normalization, and summaries of high density oligonucleotide array probe level data.Biostatistics, 3,4 (2):249-264.
    [3] Lozano R, Naghavi M, Foreman K, et al.Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010:a systematic analysis for the Global Burden of Disease Study 2010.Lancet, 2,0:2 095-128.
    [4] Murray CJ, Vos T, Lozano R, et al.Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010:a systematic analysis for the Global Burden of Disease Study 2010.Lancet, 2,0:2 197-223.
    [5] Moran AE, Forouzanfar MH, Roth GA, et al.The global burden of ischemic heart disease in 1990 and 2010:the Global Burden of Disease 2010 study.Circulation, 4,9:1 493-501.
    [6] Moran AE, Forouzanfar MH, Roth GA, et al.Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010:the Global Burden of Disease 2010 study.Circulation, 4,9:1 483-492.
    [7] Montagna P, Cortelli P, Avoni P, et al.Clinical features of fatal familial insomnia:phenotypic variability in relation to a polymorphism at codon 129 of the prion protein gene.Brain Pathol, 8,8:515-520.
    [8] 喻思扬, 王燕, 刘洋, 等.炎性体在动脉粥样硬化等心血管疾病中的作用及机制.中国动脉硬化杂志, 4,2 (12):1 281-286.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

LI Xia, WANG Mei, MA Yi-Tong, XIE Xiang, YANG Yi-Ning, MA Xiang, CHEN You, LUO Jun-Yi, LIU Fen. The Screening and the Functional Pathway Analysis of Differential Genes in Patients with Coronary Heart Disease in Uygur, Kazakh, and Han Population of Xinjiang[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(12):1238-1242.

Copy
Share
Article Metrics
  • Abstract:1415
  • PDF: 1178
  • HTML: 0
  • Cited by: 0
History
  • Received:March 09,2016
  • Revised:September 02,2016
  • Online: February 09,2017
Article QR Code

You are the 47023 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025