As a high incidence of deep vein thrombosis, high-risk disease worthy of research, animal model of deep vein thrombosis lay the foundation for the study of deep vein thrombosis. There are many types of animal thrombosis model, the murine animal models are the most common, while non-murine animal models are relatively few. A review on the thrombus model of the non-murine large animal model, generalizing the production methods, evaluation mechanisms, research progresses, advantages and disadvantages, for future clinical research provide important reference for venous thromboembolic disease.