Extracellular matrix (ECM), formed in organ growth, plays an important role in many human diseases.Hyaluronic acid (HA ) is one of the main components of the ECM, which plays an important role in tumor cell growth, differentiation, metastasis and angiogenesis. The expression of inflammatory genes is stimulated by various immune cells to stimulate the expression of HA in the damaged site. Macro- and microangiopathies are the major complications of many diseases such as diabetes, due to the close contact between the metabolism and HA synthesis, and it is possible to make HA and diabetes and other diseases have close contact. Vascular smooth muscle cell (VSMC) derived HA promotes the formation of new intima after vascular injury, and HA may be a potential target for the treatment of cardiovascular disease.This article mainly reviewed the relationship between HA and vascular disease.