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Regulation Role of Peroxiredoxins Involved into MAPK Signalling Pathways
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1.Department of Pathophysiology, University of South China, Hengyang, Hunan 421001, China;2.Institute of Cardiovascular Research ＆ Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China;3.Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, U.S.A.)

Clc Number:

R363

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    Abstract:

    Peroxiredoxins are highly conserved peroxidases. Although the thioredoxin peroxidase activity of peroxiredoxin (Prx) is important to maintain low levels of endogenous hydrogen peroxide, Prx has also been shown to promote hydrogen peroxide-mediated signalling. Mitogen activated protein kinase (MAPK) signalling pathways mediate cellular responses to a variety of stimuli, including reactive oxygen species (ROS). Here we review the evidence that Prx can act as both sensors and barriers to the activation of MAPK and discuss the underlying mechanisms involved, focusing in particular on the relationship with thioredoxin.

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GUO Fang, FU Min-Gui, JIANG Zhi-Sheng. Regulation Role of Peroxiredoxins Involved into MAPK Signalling Pathways[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(11):1163-1168.

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History
  • Received:May 31,2016
  • Revised:July 21,2016
  • Online: December 02,2016
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