Aim To summarize the clinical characteristics and prognosis of psoriasis complicated with coronary heart disease (CHD). Methods A retrospective analysis was performed on 15 patients diagnosed with psoriasis and primary CHD by coronary angiography. The traditional CHD risk factors, the situation of the first cardiovascular event, the characteristics of coronary artery lesion and follow-up results of cardiovascular disease events and psoriasis were analyzed. Results The age of onset CHD in patients with psoriasis was 55.13±10.90 years old, and traditional risk factors for CHD were 3.20±1.01 average per case. There were 11 cases (73.33%) of acute coronary syndrome in 15 cases, including 5 cases of acute ST-segment elevation myocardial infarction, 3 cases of acute non ST-segment elevation myocardial infarction, 3 cases of unstable angina pectoris. Coronary angiography showed single vessel lesion in 4 cases (26.67%), double vessel lesion in 3 cases (20.0%) and three vessel lesion in 6 cases (40.0%), left main coronary artery lesion in 2 cases (13.33%), left main coronary artery lesion plus three vessel lesion in 1 case (6.67%). 11 cases (73.33%) were diffuse lesions, among them, 2 cases (13.33%) were diffuse lesion with severe calcification. Percutaneous coronary intervention (PCI) was administered in 11 patients. The average follow-up time was 16.33±8.65 months, and 3 patients had recurrent angina, 2 cases of them were treated with PCI again. Psoriasis area and severity index (PASI) score of 15 patients at the last follow-up was significantly lower than that at the admission (8.98±1.34 vs 12.91±1.10, P＝0.01). Conclusions Patients with psoriasis and CHD are more acute onset. The degree of coronary artery lesion is heavy, and the incidence of cardiovascular events is higher during the follow-up period. The use of statins may also have a certain degree of improvement in the condition of psoriasis.