Monocyte-derived microparticles (MMP) are small bubble-shaped particles released by stressed monocyte. MMP have multiple functions, such as causing endothelia dysfunction, proinflammatory activity and procoagulant activity, which play an important role in the process of the pathology of coronary heart disease. At the same time, some risk factors of coronary heart disease can promote the generation of MMP. Therefore, MMP have the potential to become the new diagnostic criteria and therapeutic targets of coronary heart disease. This paper mainly summarizes new research progress of relationship between MMP and coronary heart disease as well as risk factors.