Aim To explore the relationship between platelet-derived growth factor-D(PDGF-D) (rs3809021 and rs7950273)genetic polymorphisms and the risk of coronary heart disease(CHD). Methods A total of 158 cases confirmed by coronary Arteriograghy(CAG) were included in CHD group and 120 healthy subjects confirmed by CAG or coronary CTA were included in control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques and gene sequencing analysis was used to analyze the polymorphism of rs3809021 and rs7950273 of PDGF-D gene and to compare its relationship with coronary artery disease between the two groups. The severity of CHD was evaluated by the number of stenotic coronary arteries and the Gensini scores respectively. Results The distributions of PDGF-D gene rs3809021 polymorphism was not significantly different between case of CHD and control group(P＞0.05),but the PDGF-D gene rs7950273 polymorphism was significantly different(P＜0.05). However, there was no statistical difference with the severity of CHD in CHD cases (P＞ 0.05). Conclusion PDGF-D gene rs7950273 allele is an important genetic susceptibility gene for CHD. It is associated with CHD, but is no associated with the severity of CHD.