The Influence of Internal Elastic Membrane Injury on Newborn Neointima
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Department of Cardiology, the People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750002, China)

Clc Number:

R363

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    Abstract:

    Aim To establish the vascular injury model through balloon dilation and strain abdominal aorta in rabbits; To analyze the relationship between vascular injury and neointima; To investigate the effect of internal elastic membrane injury on restenosis after percutaneous coronary intervention. Methods The femoral artery puncture was performed in 32 male New Zealand white rabbits, through lead wire feeding balloon. Blood vessel injury model was established by balloon dilatation and strain of abdominal aorta. After 28 days, the rabbits were sacrificed and the injured blood vessels were isolated. The fixation, embedding and staining were performed. Computer image analysis software was used to measure the thickness of the newborn neointima, and to determine the integral of vascular injury. Results The integral of vascular injury was positively correlated with the thickness of newborn neointima. The fitting curve between the integral of vascular injury and the thickness of newborn neointima was the S-shaped cubic curve. Conclusion Internal elastic membrane injury accelerates intimal hyperplasia.

    Reference
    [1] 张文广, 裴汉军, 吴永健, 等.药物洗脱支架治疗糖尿病合并冠状动脉支架内再狭窄远期疗效及安全性观察.中国循环杂志, 3,8(2):96-99.
    [2] Yin RX, Yang DZ, Wu JZ.Nanoparticle drug- and gene-eluting stents for the prevention and treatment of coronary restenosis.Theranostics, 4,4(2):175-200.
    [3] Vorpahl M, Schnhofer-Merl S, Michaelis C, et al.The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury:implications for neointima formation and restenosis.PLoS One, 2014, 9(7):e101 519
    [4] Zheng GH, Liu JP, Wang NS, et al.Systematic review of Chinese herbal medicines for preventing in-stent coronary restenosis after percutaneous coronary intervention.Evid Based Complement Alternat Med, 2,2:253 409.
    [5] Sandow SL, Gzik DJ, Lee RMKW.Arterial internal elastic lamina holes:Relationship to function?.J Anat, 9,4(2):258-266.
    [6] Lim KS, Bae1 IH, Kim JH, et al.Mechanical and histopathological comparison between commercialized and newly designed coronary bare metal stents in a porcine coronary restenosis model.Chonnam Med J, 3,9(1):7-13.
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YUAN Ji-Xiang, LIU Zhen-Ni, QU Lin-Guang. The Influence of Internal Elastic Membrane Injury on Newborn Neointima[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(8):793-795.

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History
  • Received:November 13,2015
  • Revised:December 21,2015
  • Online: July 25,2016
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