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NADPH Oxidase Nox4 Regulates the Protective Effect of Fenofribate Against Cardiac Hypertrophy
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Affiliation:

1.Guangdong No.2 Provicial People’s Hospital, Guangzhou, Guangdong 510317;2.Sun Yat-sen University, Guangzhou, Guangdong 510000;3.The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000)

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R5

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    Abstract:

    Aim To elucidate the relation between NADPH oxidase Nox4 and the protective effect of fenofribate against cardiac hypertrophy. Methods Abdominal aorta coarctation (AAC)-induced hypertensive rats were constructed to observe the effect of fenofribate on left ventricular hypertrophy. Results Fenofribate could inhibit left ventricular hypertrophy in AAC-induced hypertensive rats. Compared with sham group, the mRNA and protein levels of NADPH oxidase Nox4 were significantly elevated in left ventricular tissue of AAC group; compared with AAC group, fenofribate reduced the mRNA and protein levels of NADPH oxidase Nox4 in left ventricular tissue in a dose-dependent manner.Conclusion Reducing NADPH oxidase Nox4 expression could be a crucial mechanism of fenofribate against hypertension-induced cardiac hypertrophy. It will provide further theoretical and experimental support for fenofribate curing hypertension- induced myocardial hypertrophy.

    Reference
    [1] Byrne JA, Grieve DJ, Bendall JK, et al.Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy.Circ Res, 3,3(9):802-805.
    [2] Maytin M, Siwik DA, Ito M, et al.Pressure overload- induced myocardial hypertrophy in mice does not require gp91phox.Circulation, 4,9(9):1 168-171.
    [3] Zhao QD, Viswanadhapalli S, Williams P, et al.NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways.Circulation, 5,1(7):643-655.
    [4] Kuroda J, Ago T, Matsushima S, et al.NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.Proc Natl Acad Sci USA, 0,7(35):15 565-570.
    [5] Shouji Matsushima, Junya Kuroda, Tetsuro Ago, et al.Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.Circ Res, 3,2(4):651-663.
    [6] Althurwi HN, Elshenawy OH, El-Kadi AO.Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.J Cardiovasc Pharmacol, 4,3(2):167-177.
    [7] Zou J, Le K, Xu S, et al.Fenofibrate ameliorates cardiac hypertrophy by activation of peroxisome proliferator-activated receptor-α partly via preventing p65-NFκB binding to NFATc4.Mol Cell Endocrinol, 3,0 (1-2):103-112.
    [8] 梁伟杰, 陈景福, 宋明才, 等.活性氧与ATP敏感性钾通道的相互作用参与高糖对H9c2心肌细胞的损伤.中国动脉硬化杂志, 5,3(11):1 081-088.
    [9] Zeng SY, Chen X, Chen SR, et al.Upregulation of Nox4 promotes angiotensin Ⅱ-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression.Can J Cardiol, 3,9(10):1 310-319.
    [10] Jia Z, Xue R, Liu G, et al.hmgb1 is involved in the protective effect of the pparα agonist fenofibrate against cardiac hypertrophy.PPAR Res, 4,4:541 394.
    [11] Huang J, Xu L, Huang Q, et al.Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress.J Cell Mol Med, 5,9(7):1 672-688.
    [12] Huang Y, Zhang H, Shao Z, et al.Suppression of endothelin-1-induced cardiac myocyte hypertrophy by PPAR agonists:role of diacylglycerol kinase zeta.Cardiovasc Res, 1,0(2):267-275.
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ZENG Si-Yu, ZHOU Chang-Hua, LAN Shu-Min, LU Hui-Qin, CHEN Yan, YAN Qiu-Jiang, YAN Peng-Ke, LIU Pei-Qing. NADPH Oxidase Nox4 Regulates the Protective Effect of Fenofribate Against Cardiac Hypertrophy[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(6):557-560.

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History
  • Received:November 05,2015
  • Revised:December 24,2015
  • Online: June 30,2016
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