Aim To study the effect of Xuefuzhuyu capsule on thrombelastography (TEG) in rats with vascular endothelial injury induced by homocysteine (Hcy). Methods SD rats were randomly divided into 6 groups:normal group, model group, Tongxinluo capsule 0.21 g/kg group, Xuefuzhuyu capsule 1.6,0.8 and 0.4 g/kg groups. Rat endothelial injury models were established by intragastric gavaged of methionine once per day for continuous 4 weeks. Meanwhile, each treated group was intragastric gavaged of corresponding drug. After 4 weeks, serum levels of Hcy and endothelin-1 (ET-1), plasma level of nitric oxide (NO), platelet (PLT) number and mean platelet volume (MPV), as well as TEG were detected. Results All doses of Xuefuzhuyu capsule could significantly reduce the serum levels of Hcy and ET-1(P＜0.01), increase the plasma level of NO and MPV, and lower the number of PLT number, with statistical significances in 0.8 g/kg group (P＜0.05). All doses of Xuefuzhuyu capsule could significantly reduce MA (P＜0.01), the R of 1.6 and 0.8 g/kg groups were significantly prolonged (P＜0.01 or P＜0.05 ), the Angle of 0.8 g/kg group showed significant decrease (P＜0.01). Conclusion Xuefuzhuyu capsule can relieve the state of platelet hyper function and high coagulation factor, and attenuate high Hcy induced injury in rats.