Analysis of Influencing Factors of Dyslipidemia in Hyperlipidemia Patients From the Perspective of Cholesterol Metabolism Markers
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1.Beijing Anzhen Hospital Affiliated to Captital Medical University & Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China;2.University of South China, Hengyang, Hunan 421001, China;3.Department of Cardiology, Beijing Changping Ditrict Hospital, Beijing 102200;4.Beijing Center for Physical and Chemical Analysis, Beijing 100089, China)

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R5

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    Abstract:

    Aim By testing cholesterol absorption and synthesis markers of hyperlipidemia patients reveals cholesterol metabolism traits and correlation between the blood lipids and other risk factors. Methods 53 hyperlipidemia patients and 50 healthy persons were enlisted to detect liver and kidney function, serum total cholesterol (TC), low density lipoprotein cholesterol (LDLC), triglyceride (TG), fasting plasma glucose (FPG) and other indicators, and serum markers of cholesterol synthesis and absorption were determined by gas chromatogram. Results Squalene, lathosterol synthesis rate in patients with hyperlipidemia were higher than those in healthy control group (P<0.05). Stigmasterol absorption markers were higher than those in healthy control group (P<0.05). Multiple linear stepwise regression analysis showed the independent influencing factors of TG were LDLC and campesterol, the independent influencing factors of TG were LDLC and desmosterol, independent factors of TC and TG in health control group were LDLC and lathosterol. Conclusions Cholesterol metabolism markers in patients with hyperlipidemia were significantly higher than those in healthy control group in squalene, lathosterol, and the decreased rate of stigmasterol cholesterol absorption that results in increasing absorption of cholesterol was lower than healthy control group. The independent risk factors affecting TC and TG of hyperlipidemia group were cholesterol synthesis (dehydrogenation cholesterol) and cholesterol absorption markers (campesterol) except LDLC.

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LI Zhi-Zhao, CHEN Pan-Pan, WANG Qi-Hui, LIU Yang, YU Zhen-Qiu, WANG Lv-Ya. Analysis of Influencing Factors of Dyslipidemia in Hyperlipidemia Patients From the Perspective of Cholesterol Metabolism Markers[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(5):490-494.

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History
  • Received:October 12,2015
  • Revised:February 18,2016
  • Online: June 30,2016
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