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Research Progress on the Relationship Between Neural Guidance Factor Netrin-1 Regulating Macrophage Migration and Atherosclerotic Plaque
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Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China)

Clc Number:

R541.4

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    Abstract:

    Atherosclerosis is recognized as a chronic inflammatory disease of the artery wall, in which monocytes/macrophages plays a key role in its development. The migration ability of monocytes/macrophages is damaged in atherosclerotic plaque, and retained in plaque. This increases plaque instability and accelerates the progression of atherosclerotic lesions. Recent studies show that neural guidance factor netrin-1, secreted by macrophages in atherosclerotic plaque, can inhibit macrophage migration out of plaque and promote the progress of atherosclerosis, through binding to receptors on the surface of macrophages. However, in the early stage of atherosclerosis, netrin-1 expressed in vascular endothelial cells is found to play a protective role in atherosclerosis.

    Reference
    [1] Libby P, Ridker PM, Hansson GK.Progress and challenges in translating the biology of atherosclerosis.Nature, 1,3(7347):317-325.
    [2] Moore KJ, Tabas I.Macrophages in the pathogenesis of atherosclerosis.Cell, 1,5(3):341-355.
    [3] Swirski FK, Nahrendorf M.Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.Science, 3,9(6116):161-166.
    [4] Mestas J, Ley K.Monocyte-endothelial cell interactions in the development of atherosclerosis.Trends Cardiovasc Med, 8,8(6):228-232.
    [5] Boring L, Gosling J, Cleary M, et al.Decreased lesion formation in CCR2－/－ mice reveals a role for chemokines in the initiation of atherosclerosis.Nature, 8,4(6696):894-897.
    [6] Gu L, Okada Y, Clinton SK, et al.Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice.Mol Cell, 8,2(2):275-281.
    [7] Feig JE, Parathath S, Rong JX, et al.Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques.Circulation, 1,3(9):989-998.
    [8] Llodra J, Angeli V, Liu J, et al.Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques.Proc Natl Acad Sci USA, 4,1(32):11 779-784.
    [9] Feig JE, Rong JX, Shamir R, et al.HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells.Proc Natl Acad Sci USA, 1,8(17):7 166-171.
    [10] Trogan E, Feig JE, Dogan S, et al.Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice.Proc Natl Acad Sci USA, 6,3(10):3 781-786.
    [11] Rajasekharan S, Kennedy TE.The netrin protein family.Genome Biol, 9,0(9):239.
    [12] Barallobre MJ, Pascual M, Del RJ, et al.The Netrin family of guidance factors:emphasis on Netrin-1 signalling.Brain Res Brain Res Rev, 5,9(1):22-47.
    [13] Ly NP, Komatsuzaki K, Fraser IP, et al.Netrin-1 inhibits leukocyte migration in vitro and in vivo.Proc Natl Acad Sci USA, 5,2(41):14 729-734.
    [14] Ramesh G.Role of Netrin-1 beyond the brain:From biomarker of tissue injury to therapy for inflammatory diseases.Recent Pat Biomark, 2,2(3):202-208.
    [15] Castets M, Mehlen P.Netrin-1 role in angiogenesis:to be or not to be a pro-angiogenic factor?.Cell Cycle, 0,9(8):1 466-471.
    [16] Mirakaj V, Thix CA, Laucher S, et al.Netrin-1 dampens pulmonary inflammation during acute lung injury.Am J Respir Crit Care Med, 0,1(8):815-824.
    [17] Paradisi A, Mehlen P.Netrin-1, a missing link between chronic inflammation and tumor progression.Cell Cycle, 0,9(7):1 253-262.
    [18] Mutz C, Mirakaj V, Vagts DA, et al.The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury.Crit Care, 0,4(5):R189.
    [19] Strizzi L, Mancino M, Bianco C, et al.Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.J Cell Physiol, 8,6(3):824-834.
    [20] van Gils JM, Ramkhelawon B, Fernandes L, et al.Endothelial expression of guidance cues in vessel wall homeostasis:Dysregulation under proatherosclerotic conditions.Arterioscler Thromb Vasc Biol, 3,3(5):911-919.
    [21] van Gils JM, Derby MC, Fernandes LR, et al.The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.Nat Immunol, 2,3(2):136-143.
    [22] Ramkhelawon B, Yang Y, van Gils JM, et al.Hypoxia induces netrin-1 and UNC5b in atherosclerotic plaques:Mechanism for macrophage retention and survival.Arterioscler Thromb Vasc Biol, 3,3(6):1 180-188.
    [23] Rosenberger P, Schwab JM, Mirakaj V, et al.Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.Nat Immunol, 9,0(2):195-202.
    [24] Wang W, Reeves WB, Ramesh G.Netrin-1 and kidney injury I:Netrin-1 protects against ischemia-reperfusion injury of the kidney.Am J Physiol Renal Physiol, 8,4(4):F739-F747.
    [25] Khan JA, Cao M, Kang BY, et al.Systemic human netrin-1 gene delivery by adeno-associated virus type 8 alters leukocyte accumulation and atherogenesis in vivo.Gene Ther, 1,8(5):437-444.
    [26] Gerszten RE, Tager AM.The monocyte in atherosclerosis—should I stay or should I go now?.N Engl J Med, 2,6(18):1 734-736.
    [27] Griffin GK, Lichtman AH.Why don’t macrophages leave atherosclerotic lesions?.Circ Res, 2,0(10):1 273-275.
    [28] Swirski FK, Nahrendorf M, Libby P.The ins and outs of inflammatory cells in atheromata.Cell Metab, 2,5(2):135-136.
    [29] Moore KJ, Fisher EA.Macrophages, atherosclerosis and the potential of netrin-1 as a novel target for future therapeutic intervention.Future Cardiol, 2,8(3):349-352.
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YI Yu-Hong, ZHANG Lu-Lu, PENG Dao-Quan. Research Progress on the Relationship Between Neural Guidance Factor Netrin-1 Regulating Macrophage Migration and Atherosclerotic Plaque[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(4):429-452.

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History
  • Received:May 24,2015
  • Revised:July 14,2015
  • Online: June 30,2016
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