Aim To study the morbidity rate of metabolic syndrome (MS) in patients with type 2 diabetes and the effects of accumulation of MS components on blood lipid profile. Methods According to the recommendation of National Lipid Association, components of MS and blood lipid profile were observed and analyzed in 3750 patients with type 2 diabetes.Results Morbidity rate of MS in type 2 diabetes in our study was 63%, and there are 1268 men (54%) and 1087 women (46%), respectively. Dyslipidemia was included in the most common combinations of MS. Morbidity rate of dyslipidemia in type 2 diabetes in our study was 58%, and there are 1322 men (60%) and 862 women (40%), respectively. With the accumulation of MS components, the levels of total cholesterol, triglyceride, low density lipoprotein cholesterol (LDLC) increased significantly, but the level of high density lipoprotein cholesterol (HDLC) decreased gradually. Conclusions We should pay more attention not only to blood glucose, but also to lipid metabolism disorder in type 2 diabetes complicated with MS. By doing so, the cardiovascular risk of patients with type 2 diabetes will be decreased.