Intraplaque angiogenesis induced by factors such as hypoxia and inflammation, plays a vital role in both occurrence and progression of atherosclerosis plaque. Not only the neovessels can undermine the stability of plaque by deteriorating inflammation and promoting intraplaque hemorrhage, which may lead to deadly acute coronary syndrome, the neovessels also can benefit the plaque by relieving oxygen, reducing cellular necrosis and providing a functional pathway to get deleterious substances out of the plaque. Although antiangiogenic therapy has been applied into clinical practice, treatment of plaques with angiogenesis are still well unanswered. This paper reviews the formation and progression of the angiogenesis in atherosclerosis, and summarizes the due effects of angiogenesis on the plaque stability and the current status of antiangiogenic therapy.