Aim To analyze the clinical characteristics, interventional therapy effect and prognosis for the 70 patients with unprotected left main coronary artery(UPLM) lesion. Methods Clinical data of 70 patients who accepted the interventional therapy for UPLM lesion were collected from January 2012 to July 2013 in our hospital. Telephone or clinic follow-up was carried out after the operation. The clinical characteristics and effect of interventional therapy for patients were analyzed, and the related factors that influenced the clinical prognosis of interventional therapy were explored.Results The 70 patients included 74.3% male and 25.7% female. The average age was 69.30±9.95 years. The average of the left ventricular ejection fraction(LVEF) was 49.0%. The median value of the estimated glomerular filtration rate(eGFR) was 56 mL/(min·1.73 mm²). The average Syntax score was 26.5 and the median value of stents length was 34 mm. All patients were followed up for average of 13.3 months. The cumulative incidence of the major adverse cardiovascular event(MACE) estimated by Kaplan-Meier was 24.5%. No severe hemorrhage complication was observed after inteventional therapy. Univariate regression analysis with COX proportional hazards model revealed that the increase of LVEF would decrease the incidence of MACE(P=0.01), and the elevation of Syntax score would increase the incidence of MACE(P=0.03). Age≥70 years tended to increase the incidence of MACE(P=0.053), while the increase of eGFR tended to reduce the incidence of MACE(P=0.05). Multivariate regression analysis with COX proportional hazards model demonstrated that LVEF and eGFR had predictive value for the MACE(P=0.016 and P=0.17), while the predictive effect of Syntax score and age≥70 years were attenuated. Conclusions The interventional therapy of UPLM disease is effective and safe. The LVEF and eGFR are the major predictors of the MACE.