Aim To investigate influence of probucol combined with rosuvastatin on carotid atherosclerotic plaque, blood lipid, inflammatory factor in patients with cerebral infarction complicated with diabetes mellitus. Methods146 patients with cerebral infarction complicated with diabetes mellitus were selected in hospital from December 2011 to December 2013, who were randomly divided into two groups. 73 patients were treated with rosuvastatin as control group. 73 patients were treated with probucol combined with rosuvastatin as observation group. Carotid artery ultrasound results, serum lipid index changes, inflammatory factor changes, S100β and NIHSS score changes, adverse reactions were compared between two groups. Results After treatment, carotid artery intima-media thickness(CAIMT), carotid intimal plaque area, detection rate of vulnerable plaque, total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDLC), high sensitivity C reactive protein(hs-CRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), S100β, urine micro albumin, NIHSS score reduced significantly in two groups, while high density lipoprotein cholesterol(HDLC) increased significantly. CAIMT, carotid intimal plaque area, detection rate of vulnerable plaque, TC, TG, LDLC, hs-CRP, IL-6, TNF-α, S100β, urine micro albumin, NIHSS score in observation group were significantly lower than control group, while HDLC was significantly higher than control group. Differences were statistically significant(P<0.05). There were no significant difference between observation group and control group in incidence of adverse reactions(abnormal liver and kidney function, dizziness headache, rash, myalgia, nausea and vomiting, gastrointestinaltract reaction, P>0.05). Conclusion Probucol combined with rosuvastatin is an effective method in treatment of cerebral infarction complicated with diabetes mellitus, which can reduce carotid atherosclerotic plaque and improve blood lipid status, decrease inflammatory factor level and has high safety.