Aim To investigate the effects of dose-dependent atorvastatin on the numbers of endothelial progenitor cells in patients with stable coronary heart disease. Methods 84 patients with stable coronary heart disease were randomly divided into treatment groups with atorvastatin (0,0, 0,0 mg/d) for 4 weeks. Circulating endothelial progenitor cells numbers were determined by immunfluorescence analysis. Results The numbers of endothelial progenitor cells were all increased by different dose atorvastatin (P<0.05), maximum at 40 mg/d and had statistical difference compared with 10 mg/d and 20 mg/d (P<0.05). Endothelial progenitor cells numbers at the dose of 80 mg/d were slightly reduced compared with 40 mg/d, but there was no statistical difference(P>0.05). Conclusion Atorvastatin dose-dependently improve the endothelial progenitor cells numbers in the patients with stable coronary heart disease.