Aim To explore the change of plasma level of the new type platelet activating protein SCUBE1 and its correlation with blood pressure in patients with essential hypertension (EH). Methods 77 EH patients screened in Physical Examination Center of the First Affiliated Hospital of Shihezi University were selected for the EH group in December 2013. 75 normal healthy persons during the same period were as the control group. Plasma level of SCUBE1 was detected by enzyme-linked immunosorbent assay. Blood pressure, waist hip ratio (WHR), body mass index (BMI), fasting blood glucose (FBG), total cholesterol, triglyceride (TG), high density lipoprotein cholesterol, low density lipoprotein cholesterol, urea nitrogen, creatinine and uric acid were measured in the two groups. Correlation between SCUBE1 and the indexes was analyzed. Results The plasma level of SCUBE1 in EH group was significantly higher than that in control group (76.95±13.87 μg/L vs 58.34±13.06 μg/L, P<0.001). Systolic blood pressure (SBP), diastolic blood pressure (DBP), WHR, BMI, FBG and TG in EH group were significantly higher than those in control group (P<0.001 or P<0.05). Correlation analysis and linear regression analysis showed that SCUBE1 was positively correlated with SBP and DBP (P<0.05). Conclusions The plasma level of SCUBE1 is increased in EH patients. SCUBE1 is positively correlated with SBP and DBP.