2025年5月20日 周二
Home > Archive>Volume 24, Issue 1, 2016 >54-58
PDF HTML XML Export Cite reminder
Characteristics of Blood Lipid Disorder in Patients with Rheumatoid Arthritis and Its Correlation with Disease Activity
Author:
Affiliation:

1.Department of Rheumatology and Immunology, Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China;2.Anzhen Hospital Affiliated to Capital Medical University & Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China)

Clc Number:

R593.22

  • Article
    • | |
  • Metrics
    • |
  • Reference [26]
    • | | | |
  • Comments
    Abstract:

    Aim To investigate the characteristics of blood lipid disorder in patients with rheumatoid arthritis (RA) and its correlation with disease activity. Methods 62 patients with RA were as the RA group, and 46 cases with age- and sex- matched healthy physical examination were as the control group. According to disease activity, RA group was divided into two subunits:active RA group and inactive RA group. General parameters and the traditional risk factors of cardiovascular disease were recorded; Body mass index (BMI) was calculated; Systolic blood pressure and diastolic blood pressure were measured; Serum triglyceride, total cholesterol (TC), low density lipoprotein cholesterol, high density lipoprotein cholesterol (HDLC), high-sensitivity C-reactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR) were detected. Differences of blood lipids, hs-CRP and ESR were compared among each group. Correlations between blood lipids and hs-CRP, ESR in RA patients were analyzed by Pearson linear correlation analysis. Results BMI of RA group was significantly higher than that of control group (P<0.05). Serum TC levels in active RA group and inactive RA group were significantly higher than that in control group (P<0.05). Serum HDLC level in active RA group was significantly lower than those in inactive RA group and control group (P<0.01), and serum HDLC level in inactive RA group was significantly lower than that in control group (P<0.01). TC/HDLC ratio in active RA group was significantly higher than those in inactive RA group and control group (P<0.01), and TC/HDLC ratio in inactive RA group was significantly higher than that in control group (P<0.05). In RA patients, serum HDLC level was negatively correlated with hs-CRP and ESR (r＝－0.532, P＝0.000; r＝－0.508, P＝0.000), and TC/HDLC was positively correlated with hs-CRP and ESR (r＝0.321, P＝0.001; r＝0.246, P＝0.030). Conclusions Blood lipids metabolic disorder in RA patient is mainly the decrease of HDLC. Serum HDLC level is significantly decreased in active RA patient, which is closely related with RA disease activity.

    Reference
    [1] 张春来, 尚小明, 纪征, 等.中老年人群类风湿关节炎合并心血管疾病的相关因素分析.中国动脉硬化杂志, 2,0(4):365-368.
    [2] Anderson J, Caplan L, Yazdany J, et al.Rheumatoid arthritis disease activity measures:American college of rheumatology recommendations for use in clinical practice.Arthritis Care Res (Hoboken), 2,4(5):640-647.
    [3] Bartoloni E, Alunno A, Bistoni O, et al.How early is the atherosclerotic risk in rheumatoid arthritis?.Autoimmunity Reviews, 0,9(10):701-707.
    [4] Hollan I, Meroni PL, Ahearn JM, et al.Cardiovascular disease in autoimmune rheumatic diseases.Autoimmunity Reviews, 3,2(10):1 004-015.
    [5] Mavrogeni S, Dimitroulas T, Bucciarelli-Ducci C, et al.Rheumatoid arthritis:An autoimmune disease with female preponderance and cardiovascular risk equivalent to diabetes mellitus:Role of cardiovascular magnetic resonance.Inflamm Allergy Drug Targets, 4,3(2):81-93.
    [6] Toms TE, Panoulas VF, Douglas KM, et al.Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?.Angiology, 1,2(2):167-175.
    [7] van Halm VP, Nielen MM, Nurmohamed MT, et al.Lipids and inflammation:Serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis.Ann Rheum Dis, 7,6(2):184-188.
    [8] Choy E, Sattar N.Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis:A challenge to conventional cardiovascular risk actions.Ann Rheum Dis, 9,8(4):460-469.
    [9] Ong KL, Wu BJ, Cheung BM, et al.Arthritis:Its prevalence, risk factors, and association with cardiovascular diseases in the united states, 1999 to 2008.Ann Epidemiol, 3,3(2):80-86.
    [10] Myasoedova E, Crowson CS, Kremers HM, et al.Total cholesterol and LDL levels decrease before rheumatoid arthritis.Ann Rheum Dis, 0,9(7):1 310-314.
    [11] Zhang J, Chen L, Delzell E, et al.The association between inflammatory markers, serum lipids and the risk of cardiovascular events in patients with rheumatoid arthritis.Ann Rheum Dis, 4,3(7):1 301-308.
    [12] Hassen Zrour S, Hassine Neffeti F, Sakly N, et al.Lipid profile in tunisian patients with rheumatoid arthritis.Clin Rheumatol, 1,0(10):1 325-331.
    [13] Welty FK.How do elevated triglycerides and low HDL cholesterol affect inflammation and atherothrombosis?.Curr Cardiol Rep, 3,5(9):400.
    [14] Marsche G, Saemann MD, Heinemann A, et al.Inflammation alters HDL composition and function:Implications for HDL-raising therapies.Pharmacol Ther, 3,7(3):341-351.
    [15] Montecucco F, Favari E, Norata GD, et al.Impact of systemic inflammation and autoimmune diseases on ApoAI and HDL plasma levels and functions.Handb Exp Pharmacol, 5,4(10):455-482.
    [16] Kinosian B, Glick H, Garland G.Cholesterol and coronary heart disease:Predicting risks by levels and ratios.Ann Intern Med, 4,1(9):641-647.
    [17] Yang D, Liu X, Xiang M.The correlation between lipids ratio and degree of coronary artery stenosis.High Blood Press Cardiovasc Prev, 1,8(2):53-56.
    [18] Choi HK, Seeger JD.Lipid profiles among us elderly with untreated rheumatoid arthritis--the third national health and nutrition examination survey.J Rheumatol, 5,2(12):2 311-316.
    [19] de Carvalho JF, Bonfa E, Borba EF.Systemic lupus erythematosus and "lupus dyslipoproteinemia".Autoimmun Rev, 8,7(3):246-250.
    [20] Steiner G, Urowitz MB.Lipid profiles in patients with rheumatoid arthritis:Mechanisms and the impact of treatment.Semin Arthritis Rheum, 9,8(5):372-381.
    [21] Baker JF, Von Feldt J, Mostoufi-Moab S, et al.Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis.Arthritis Care Res (Hoboken), 4,6(11):1 612-618.
    [22] Zarpellon RS, Dias MM, Skare TL.Nutritional profile in rheumatoid arthritis.Rev Bras Reumatol, 4,4(1):68-72.
    [23] Bag-Ozbek A, Giles JT.Inflammation, adiposity, and atherogenic dyslipidemia in rheumatoid arthritis:Is there a paradoxical relationship?.Curr Allergy Asthma Rep, 5,5(2):497.
    [24] Baeten D, Boots AM, Steenbakkers PG, et al.Human cartilage GP-39＋, CD16＋ monocytes in peripheral blood and synovium:Correlation with joint destruction in rheumatoid arthritis.Arthritis Rheum, 0,3(6):1 233-243.
    [25] Fontana L, Eagon JC, Trujillo ME, et al.Visceral fat adipokine secretion is associated with systemic inflammation in obese humans.Diabetes, 7,6(4):1 010-013.
    [26] Peters MJ, Symmons DP, McCarey D, et al.EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis.Ann Rheum Dis, 0,9(2):325-331.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

PAN Li-Li, WANG Tian, WANG Lv-Ya. Characteristics of Blood Lipid Disorder in Patients with Rheumatoid Arthritis and Its Correlation with Disease Activity[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2016,24(1):54-58.

Copy
Share
Article Metrics
  • Abstract:782
  • PDF: 748
  • HTML: 0
  • Cited by: 0
History
  • Received:January 26,2015
  • Revised:March 30,2015
  • Online: November 19,2018
Article QR Code

You are the 46724 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025