Aim To investigate the influence of rate-pressure product （RPP） on right subclavian artery plaque detection rate. Methods A total of 5852 participants were selected with stratified random sampling from the 101510 workers of Tangshan KaiLuan company who received the health examination. 5154 of them with integral data were recruited into the survey. The observation population was divided into four groups according to RPP collected during 2010～2011 health examinations: quartile 1 （RPP＜7707）,quartile 2 （7707≤RPP＜8970）,quartile 3 （8970≤RPP＜10401）,quartile 4 （RPP≥10401）. Multivariate logistic regression analysis was used to analyze the influence of RPP on detection rate of right subclavian artery plaque. Results （1）The study included 5154 participants（male 3100 cases，female 2054 cases） with a mean age of 54.83 years. （2） The right subclavian artery plaque detection rate was 33.1%. The right subclavian artery plaque detection rate for the above quartiles of RPP were 27.1%,30.4%,35.1% and 39.8%,respectively. （3）After adjusting for confounding parameters such as age,gender and other risk factors,multiple logistic regression analysis showed that the risk of detection of right subclavian artery plaque was increased in quartile 3 and 4 of RPP compared with quartile 1,and the OR values were 1.22（95%CI 1.01～1.47） and 1.28（95%CI 1.05～1.55）,respectively. Conclusion Increased RPP increase the detection risk of right subclavian artery plaque.