Aim To investigate the clinical features of the risk factors of premenopausal women with coronary heart disease（CHD）.Methods From October 2013 to May 2014,60 premenopausal women patients diagnosed as coronary heart disease were included. According to the coronary angiography（CAG） result,all patients were divided into CHD group （35 patients） and control group （25 patients）. All of the 60 cases were measured to determinate the level of total cholesterol （TC）,triglycerides （TG）,high density lipoprotein cholesterol （HDLC）,low density lipoprotein cholesterol （LDLC）,blood uric acid （UA） and routine blood,age,weight,family history of coronary heart disease,hypertension history and diabetes history in details.Results Compared with the control group,there were significant higher proportion of hypertension,family history of coronary heart disease,diabetes,systolic blood pressure （SBP） and increased TG,UA,neutrophils,monocytes levels （P<0.05） and decreased HDLC,hemoglobin（Hb） level in CHD group. Multivariate Logistic regression analysis showed diabetes,TG,UA,SBP and decreased HDLC were independent risk factors for CHD group patients.Conclusions The study suggests that TG,hypertension,SBP,diabetes,UA and lower HDLC levels were independent risk factors for premenopausal women with coronary heart disease.