Inflammation mediated endothelial dysfunction plays an important role in the occurrence and development of obesity-induced cardiovascular disease. Omentin is a kind of anti-inflammatory adipokines, and there is a close relationship between obesity endothelial function. Regular exercise can produce anti-inflammatory effect, improve endothelial function in obese subjects and thereby reduce the risk of cardiovascular disease, through enhancing the expression and secretion of omentin in obesity. This paper is a review of recent research status of this field. It may provide a theoretical thinking for the further research of biological mechanisms of the regular exercise to improve the obesity-related vascular endothelial function.