Familial hypercholesterolemia is an autosomally dominant disease and clinically characterized by elevated serum levels of total and low density lipoprotein cholesterol,the presence of tendon xanthomas and premature coronary artery disease.Clinical and genetic therapies are the main treatments of familial hypercholesterolemia.Several drugs and genetic research are emerging to help improve the treatments of this disease in recent years.In this review,we will present the recent developments in the clinical and genetic treatments of familial hypercholesterolemia.