Aim To investigate the serum level of Apelin and its clinical significance in essential hypertension （EH） patients accompanied with coronary heart disease （CHD）.Methods 96 EH cases from the 1st June 2013 to the 1st December 2013 were divided into EH＋CHD group and EH group according to the presence of CHD.Fasting venous blood was drawn to detect the serum Apelin level and biochemical parameters.Blood pressure and body mass index （BMI） were recorded.Results （1）The serum Apelin level in EH＋CHD group was significantly lower than that in EH group （1.83±0.71 μg/L vs 2.28±0.82 μg/L,P<0.05）.（2）The serum level of Apelin was lower with the increase of Syntax score.（3）The serum Apelin level was negatively correlated with BMI,systolic blood pressure,diastolic blood pressure and fasting plasma glucose in EH＋CHD group.（4）Logistic regression analysis results showed that low serum Apelin was an independent risk factor for CHD in EH patients （OR＝0.475,95%CI: 0.163～0.838,P<0.05）.