Aim To investigate the effect of obstructive seep apnea hypoventilation syndrome （OSAHS） on the morbidity of contrast-induced nephropathy （CIN） in patients with coronary heart disease （CHD）.Methods 110 patients were divided into CHD without OSAHS group （n＝48） and CHD with OSAHS group （n＝62） according to diaognostic coronary angiography （CAG） and polysomnography （PSG）.Before and after coronary angiography or percutaneous coronary intervention （PCI）,the level of serum creatinine was compared between the two groups.The morbidity of CIN was compared between the two groups.Results The difference of the level of serum creatinine was not statistically significant between the two groups before coronary angiography （t＝－0.733,P＝0.465）.The difference of the level of serum creatinine was statistically significant between the two groups after coronary angiography or percutaneous coronary intervention （t＝－2.486,P＝0.014 t＝－2.921,P＝0.004）.The morbidity of CIN was higher in CHD with OSAHS group （χ²＝4.013,P＝0.045）.Conclusion OSAHS is a risk factor of CIN in patients with CHD.