Aim To explore the association of serum Adropin level with in-stent restenosis （ISR） after stent implantation in coronary artery. Methods A total of 176 patients underwent coronary artery stent implantation were divided into two groups of ISR （18 cases） and Non-ISR （158 cases） according to coronary angiography at 10～12 months later after stent implantation. The serum Adropin level, high sensitivity C-reactive protein （hs-CRP） and other metabolic parameters were measured. Insulin resistance index （IRI） was calculated. Results Serum Adropin level was significantly lower, whereas hs-CRP, fasting plasma insulin, IRI were significantly higher in group ISR than those in group Non-ISR （ P<0.05）. Diabetes were more common in patients with ISR than those without ISR （P<0.05 ）. Multivariate regression analysis revealed that Adropin was the independent risk factor for ISR （P<0.01）. Adropin was negatively correlated with IRI and hs-CRP （P<0.01）. Conclusions Lower serum Adropin level was significantly associated with ISR after coronary artery stent implantation, indicating the possible role of Adropin in the prevention of ISR.