Aim To explore the relationship between plasma β2-microglobulin （β2-MG）,ankle-brachial index （ABI） and blood pressure variability （BPV） in aged patients with hypertension. Methods 269 cases of aged patients with primary hypertension and 186 cases of middle aged patients with primary hypertension,were compared with 178 cases of aged healthy check-up.Analysis of variance was used to analyze the blood pressure variability rate and plasma β2-MG among the groups.According to ABI the aged patients with hypertension group was divided into two subgroups: ABI＜0.9 subgroup （74 cases） and ABI≥0.9 subgroup （195 cases）,and the blood pressure variability and plasma β2-MG between two subgroups were compared. Results The 24 h systolic blood pressure variability （24hSBPV） and 24 h diastolic blood pressure variability （24hDBPV） in aged patients with hypertension group were significantly increased,compared with the aged control group （21.50%±4.01% vs 15.16%±5.17%,15.99%±4.28% vs 11.24%±3.83%） and middle-aged hypertension group （21.50%±4.01% vs 19.34%±6.28%,15.99%±4.28% vs 13.91%±5.43%） （P<0.05）.24hSBPV,24hDBPV,and plasma β2-MG of ABI＜0.9 subgroup were higher than those of ABI≥0.9 subgroup （P<0.05）. Conclusion Both blood pressure variability and the level of plasma β2-MG in aged patients with hypertension are increased The blood pressure variability and the level of plasma β2-MG in aged patients with hypertension accompanying ABI＜0.9 are increased more significantly.