Aim The roles of monocyte/macrophage subsets （Mon1, Mon2, Mon3） are different on atherosclerotic inflammation. The aim of this article is to identify the distribution of monocyte Mon2 in patients with different clinical types of coronary artery disease, and to reveal correlation between monocyte Mon2 and atherosclerosis. Methods Totally 90 patients with coronary artery disease （stable angina pectoris, SAP, 28 unstable angina pectoris, UAP, 30 and acute myocardial infarction, AMI, 32） and 5 controls were enrolled. Mon2 were evaluated with CD14⁺CD163⁺using flow cytometry. Correlation between Mon2 and coronary score was evaluated using unitary linear recursive analysis. Results Monocyte Mon2 proportions were significantly different between patients with coronary artery disease and controls （P0.001）, furthermore among patients with coronary artery disease, Mon2 proportions had significant difference in SAP （24.3 %, 19.1%～29.5%）, UAP （ 11.1 %, 6.1%～16.9%） and AMI group（ 8.2 %, 3.3%～13.1%） , respectively. Value of CD163 MFI had significant difference in SAP （1.58, 1.38～1.78）, UAP （1.21, 1.04～1.39） and AMI group （1.10, 0.94～1.27）, respectively. However, no correlation was found between coronary score and Mon2 proportion and CD163 MFI. Conclusions The distribution of monocyte Mon2 varies was correlated with type of coronary artery disease.