Aim To evaluate the clinical effect of Salvianolate on patients with acute myocardial infarction （AMI）by detecting the level of sCD40L and E-selectin and P-selectin in blood serum. Methods 120 patients with AMI were enrolled in the study and were randomly assigned to the Salvianolate group（60 patients）and the routine group （60 patients）. All patients were treated with conventional drugs, while the Salvianolate group was administered with Salvianolale additionally for 14 days. The change of symptoms was observed and the levels of sCD40L and E-selectin、P-selectin was recorded before and after the treatments respectively. Results Both Salvianolate group and routine group could ameliorate the symptom and the level of sCD40L, E-selectin and P-selectin in the two groups was decreased. Compared with routine group，Salvianolate further decreased the level of sCD40L and E-selectin and P-selectin （P<0.05）. Serum sCD40L was significantly correlated with P-selectin （r0.698，P<0.01）, while serum sCD40L was significantly correlated with E-selectin （r0.692，P<0.01）. Conclusion Salvianolate significantly improved the symptoms of AMI patients. That reduction of sCD40L, E-selectin and P-selectin might be one of the mechanisms responsible for improving clinic syndrome.