Aim To evaluate the independent risk factors for restenosis in patients treatment of coronary stenting. Methods One hundred and seventy one patients who underwent the coronary stent implantation with a follow-up of angiography from July 2009 to November 2011 were included in this retrospective study. Among the 171 subjects, 48 patients with 56 target diagnosed of restenosis according to the angiography were defined as case group, and 123 patients with 133 target vessels without restenosis were deemed as control group. The logistic regression model was applied to evaluate the independent risk factors for restenosis in patients treatment of coronary stenting. Results Univariate analysis showed that Univariate analysis showed that stenosis prior PCI ＞90% （χ²4.71，P0.03）, diameter of the stent ≤3 mm （χ²27.92，P0.00）, length of the leision＞15 mm （χ²4.67，P0.03）, residual stenosis ＞5%（χ²10.05，P0.00）, smoking （χ²4.78，P0.03）, diabetes （χ²4.72，P0.03）, irregular anticoagulation（χ²6.70，P0.01） were associated with restenosis in patients treated with coronary stenting. Logistic regression demonstrated that diameter of the stent ≤3 mm （OR4.34, 95%CI:2.01～8.38，P0.02）, residual stenosis ＞5% （OR2.2, 95%CI: 1.56～4.88，P0.03） and irregular anticoagulation （OR1.88, 95%CI:1.21～3.68，P0.04） were the independent risk factors for restenosis. And the proportional hazards model showed patients with diameter of the stent ≤3 mm had the higher risk for restenosis than that with ＞3 mm （HR3.53, 95%CI:2.08～5.99, P0.00） . Conclusion Patients treated with smoler diameter stent, serious residual stenosis and irregular anticoagulation had the higher risk to develop restenosis after coronary stenting and this kind of patients should be taken seriously.